Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fritz, E; Hammer, HF; Lipp, RW; Högenauer, C; Stauber, R; Hammer, J.
Effects of lactulose and polyethylene glycol on colonic transit.
ALIMENT PHARMACOL THERAPEUT. 2005; 21(3): 259-268.
Doi: 10.1111/j.1365-2036.2005.02244.x
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- Führende Autor*innen der Med Uni Graz
- Hammer Heinz
- Co-Autor*innen der Med Uni Graz
- Hoegenauer Christoph
- Lipp Rainer
- Stauber Rudolf
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- Abstract:
- BACKGROUND: The effects of lactulose and polyethylene glycol on colonic transit are poorly established. AIM: To assess the effects of these laxatives on colonic transit in normal subjects. METHODS: Colonic transit (mean residence time, cumulative counts in stool, counts remaining in the proximal or distal colon) was measured scintigraphically in normal subjects on the second and third day of a 3-day ingestion of 67-134 g/day lactulose, or 59 g/day polyethylene glycol. RESULTS: At similar stool weight (lactulose: 653 +/- 120 g/day; polyethylene glycol: 522 +/- 66 g/day), transit was significantly slower during 99 g/day lactulose when compared with 59 g/day polyethylene glycol; this was most pronounced in the distal colon (mean residence time: lactulose - 403 +/- 55 min; polyethylene glycol - 160 +/- 41.9 min). Short chain fatty acid concentration in 24-h stool correlated significantly with counts remaining in the distal colon at 12 h (r = 0.79, P = 0.001). Increasing lactulose doses were significantly associated with increasing stool weight (r = 0.79) and shorter mean residence time in the total (r = -0.56) and distal colon (r = -0.64). The sum of faecal carbohydrates plus short chain fatty acids was associated with stool weight (r = 0.95, P < 0.001). CONCLUSION: Lactulose accelerates colonic transit. However, compared with polyethylene glycol, transit during lactulose is prolonged.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Carbohydrates - analysis
- Cathartics - pharmacology
- Colon - drug effects
- Constipation - drug therapy
- Fatty Acids, Volatile - analysis
- Feces - chemistry
- Female - chemistry
- Gastrointestinal Transit - drug effects
- Humans - drug effects
- Indium Radioisotopes - diagnostic use
- Lactulose - pharmacology
- Male - pharmacology
- Middle Aged - pharmacology
- Polyethylene Glycols - pharmacology
- Statistics, Nonparametric - pharmacology
- Stimulation, Chemical - pharmacology