Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Silbernagel, G; Hoffmann, MM; Grammer, TB; Boehm, BO; März, W.
Uric acid is predictive of cardiovascular mortality and sudden cardiac death in subjects referred for coronary angiography.
Nutr Metab Cardiovasc Dis. 2013; 23(1):46-52
Doi: 10.1016/j.numecd.2011.02.008
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- Führende Autor*innen der Med Uni Graz
- Silbernagel Günther
- Co-Autor*innen der Med Uni Graz
- März Winfried
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- Abstract:
- High serum uric acid (SUA) is suggested to be causally involved in the pathogenesis of vascular disease. The present study aimed to investigate whether SUA independently predicts all-cause mortality, cardiovascular mortality and sudden cardiac death in subjects scheduled for coronary angiography. We studied participants of the LUdwigshafen RIsk and Cardiovascular health (LURIC) study. A total of 3245 individuals were included in the analysis. There was a follow-up for all-cause mortality, cardiovascular mortality, and sudden cardiac death with a mean (±standard deviation) duration of 7.3 (±2.3) years. Sex-specific quartiles of SUA were established and multivariate statistical models were used. A total of 730 deaths occurred during the follow-up. Among these, 473 (64.8%) were accounted for by cardiovascular diseases. Sudden cardiac death occurred in 184 (25.2%) cases. Adjusting for sex and age subjects in the fourth SUA quartile had increased all-cause (hazard ratio (HR) = 1.68, p < 0.001) and cardiovascular (HR = 2.00, p < 0.001) mortality compared to individuals in the first quartile. Furthermore, high SUA was a risk factor for sudden cardiac death (HR = 2.27, p < 0.001). These associations remained significant including cardiovascular risk factors and the severity of coronary atherosclerosis as covariates in the models. After additional adjustment for medication use statistical significance for the association between the SUA quartiles and all-cause mortality disappeared. High SUA independently indicates increased risk for cardiovascular and sudden cardiac death in subjects referred for coronary angiography. Copyright © 2011 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Cardiovascular Diseases - blood Cardiovascular Diseases - mortality Cardiovascular Diseases - radiography
- Coronary Angiography -
- Coronary Artery Disease - mortality Coronary Artery Disease - radiography
- Death, Sudden, Cardiac -
- Female -
- Humans -
- Male -
- Middle Aged -
- Prospective Studies -
- Risk Factors -
- Uric Acid - blood
- Find related publications in this database (Keywords)
- Uric acid
- Coronary artery disease
- All-cause mortality
- Cardiovascular mortality
- Sudden cardiac death