Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Plank, G; Prassl, AJ; Augustin, C.
Computational Challenges in Building Multi-Scale and Multi-Physics Models of Cardiac Electro-Mechanics.
Biomed Tech (Berl). 2013; 58 Suppl 1(1):
Doi: 10.1515/bmt-2013-4318
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- Führende Autor*innen der Med Uni Graz
- Plank Gernot
- Co-Autor*innen der Med Uni Graz
- Augustin Christoph
- Prassl Anton
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- Abstract:
- Despite the evident multiphysics nature of the heart - it is an electrically controlled mechanical pump - most modeling studies considered electrophysiology and mechanics in isolation. In no small part, this is due to the formidable modeling challenges involved in building strongly coupled anatomically accurate and biophyically detailed multi-scale multi-physics models of cardiac electro-mechanics. Among the main challenges are the selection of model components and their adjustments to achieve integration into a consistent organ-scale model, dealing with technical difficulties such as the exchange of data between electro-physiological and mechanical model, particularly when using different spatio-temporal grids for discretization, and, finally, the implementation of advanced numerical techniques to deal with the substantial computational. In this study we report on progress made in developing a novel modeling framework suited to tackle these challenges.
- Find related publications in this database (Keywords)
- cardiac electrophysiology
- cardiac mechanics
- bidomain model
- Purkinje system
- algebraic multigrid