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Hofer, E; Sanchez-Quintana, D; Arnold, R.
Rapid Pacing Induces Fractionation of the Activation Wavefront into Multiple Wavelets.
Biomed Tech (Berl). 2013; 58 Suppl 1(1): Doi: 10.1515/bmt-2013-4421
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Leading authors Med Uni Graz: Hofer Ernst
Co-authors Med Uni Graz: Arnold Robert
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Abstract:: Atrial flutter and atrial fibrillation can be caused by heterogeneities in membrane function as well as in macro- and microstructure. Rapid pacing techniques combined with potential recording techniques can help to localize critical arrhythmogenic substrates within the atrium. This work describes the heterogeneity of local conduction in the cavotricuspid isthmus (CTI) during electrophysiological experiments with Rabbit hearts. By means of rapid pacing techniques it can be shown, that local blockade of excitation spread can be predicted using appropriate pacing protocols. The pre-block behaviour is characterized by a substantial increase in the degree of fractionation and in a decrease of amplitude in extracellular potentials.
Find related publications in this database (Keywords): atrial flutter; rapid pacing; complex fractionated atrial electrogram; electrophysiological experiment