Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Boehm, S; Huck, S; Drobny, H; Singer, EA.
Pertussis toxin abolishes the inhibition of Ca2+ currents and of noradrenaline release via alpha 2-adrenoceptors in chick sympathetic neurons.
Naunyn Schmiedebergs Arch Pharmacol. 1992; 345(5):606-609
Doi: 10.1007/BF00168956
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- Führende Autor*innen der Med Uni Graz
- Böhm Stefan
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- Abstract:
- Effects of alpha 2-adrenoceptor agonists on whole-cell Ca2+ currents and 3H-noradrenaline release were investigated by applying the patch-clamp technique and electrical field stimulation to cultured embryonic chick sympathetic neurons. A 24-h exposure of the sympathetic neurons to pertussis toxin (100 ng/ml) abolished both the alpha 2-adrenoceptor-mediated inhibition of Ca2+ currents and the modulation of noradrenaline release caused by noradrenaline (1 mumol/l; in the presence of 10 mumol/l cocaine) or the alpha 2-adrenoceptor agonists 5-bromo-6-(2-imidazolin-2- ylamino)quinoxaline (UK 14,304, 10 mumol/l) and clonidine (10 mumol/l). These results suggest that the alpha 2-autoreceptor-mediated inhibition of noradrenaline release from chick sympathetic neurons operates through the modulation of Ca2+ channels via pertussis-toxin-sensitive GTP-binding-proteins.
- Find related publications in this database (using NLM MeSH Indexing)
- Adrenergic alpha-Agonists - pharmacology
- Animals -
- Calcium - physiology
- Cells, Cultured -
- Chick Embryo -
- Norepinephrine - secretion
- Pertussis Toxin -
- Receptors, Adrenergic, alpha - drug effects
- Sympathetic Nervous System - drug effects
- Tritium -
- Virulence Factors, Bordetella - toxicity
- Find related publications in this database (Keywords)
- CHICK SYMPATHETIC NEURONS
- ALPHA-2-ADRENOCEPTORS
- PERTUSSIS TOXIN
- CA2+ CURRENTS
- H-3-NORADRENALINE RELEASE