Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bacsa, B; Bosze, S; Kappe, CO.
Direct solid-phase synthesis of the beta-amyloid (1-42) peptide using controlled microwave heating.
J Org Chem. 2010; 75(6): 2103-2106.
Doi: 10.1021/jo100136r
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Bacsa Bernadett
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- Abstract:
- Standard linear Fmoc/t-Bu solid-phase synthesis of the 42-mer beta-amyloid (1-42) peptide was achieved under controlled microwave conditions at 86 degrees C using inexpensive DIC/HOBt as coupling reagent on ChemMatrix resin. In order to avoid racemization of the sensitive amino acids, the coupling of the three His residues in the difficult peptide sequence was performed at room temperature. The desired peptide was obtained within 15 h overall processing time in high yield and purity (78% crude yield).
- Find related publications in this database (using NLM MeSH Indexing)
- Amino Acid Sequence -
- Amyloid beta-Peptides - chemical synthesis Amyloid beta-Peptides - chemistry
- Chromatography, High Pressure Liquid -
- Microwaves -
- Molecular Sequence Data -
- Molecular Structure -
- Peptide Fragments - chemical synthesis Peptide Fragments - chemistry
- Peptides - chemical synthesis Peptides - chemistry
- Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization -