Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bacsa, B; Desai, B; Dibó, G; Kappe, CO.
Rapid solid-phase peptide synthesis using thermal and controlled microwave irradiation.
J Pept Sci. 2006; 12(10): 633-638.
Doi: 10.1002/psc.771
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Bacsa Bernadett
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- Abstract:
- A rapid and efficient microwave-assisted solid-phase synthesis method is described for the preparation of the nonapeptide WDTVRISFK, using conventional Fmoc/Bu(t) orthogonal protection strategy. The synthesis protocol is based on the use of cycles of pulsed microwave irradiation with intermittent cooling of the reaction during the removal of the Fmoc protecting group and during the coupling. The desired nonapeptide was obtained in highest yield and purity by employing MicroKan technology. The chemical reactions were carried out in a single-mode microwave reactor, equipped with a fiber-optic probe to monitor the reaction temperature continuously.
- Find related publications in this database (using NLM MeSH Indexing)
- Biochemistry - methods
- Microwaves -
- Peptides - chemical synthesis Peptides - chemistry
- Find related publications in this database (Keywords)
- solid-phase peptide synthesis
- microwave irradiation
- microwave-assisted organic synthesis
- microwave-assisted peptide synthesis
- MicroKan