Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pleyer, L; Germing, U; Sperr, WR; Linkesch, W; Burgstaller, S; Stauder, R; Girschikofsky, M; Schreder, M; Pfeilstocker, M; Lang, A; Sliwa, T; Geissler, D; Schlick, K; Placher-Sorko, G; Theiler, G; Thaler, J; Mitrovic, M; Neureiter, D; Valent, P; Greil, R.
Azacitidine in CMML: matched-pair analyses of daily-life patients reveal modest effects on clinical course and survival.
Leuk Res. 2014; 38(4):475-483
Doi: 10.1016/j.leukres.2014.01.006
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- Co-Autor*innen der Med Uni Graz
- Linkesch Werner
- Theiler Georg
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- Abstract:
- Recent data suggest that azacitidine may be beneficial in CMML. We report on 48 CMML-patients treated with azacitidine. Overall response rates were high (70% according to IWG-criteria, including 22% complete responses). Monocyte count and cytogenetics adversely affected survival, whereas age, WHO-type, FAB-type, and spleen size did not. Matched-pair analyses revealed a trend for higher two-year-survival for azacitidine as compared to best supportive care (62% vs. 41%, p=0.067) and longer OS for azacitidine first-line vs. hydroxyurea first-line (p=0.072, median OS 27.7 vs. 6.2 months). This report reinforces existing evidence that azacitidine is safe and efficacious in both myelodysplastic and myeloproliferative CMML. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Activities of Daily Living -
- Adult -
- Aged -
- Aged, 80 and over -
- Antimetabolites, Antineoplastic - therapeutic use
- Azacitidine - therapeutic use
- Disease Progression -
- Female -
- Humans -
- Leukemia, Myelomonocytic, Chronic - drug therapy
- Leukemia, Myelomonocytic, Chronic - mortality
- Male -
- Matched-Pair Analysis -
- Middle Aged -
- Survival Analysis -
- Find related publications in this database (Keywords)
- Matched-pair analysis
- CMML
- Chronic myelomonocytic leukemia
- Azacitidine
- Austrian Azacitidine Registry