Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pippal, JB; Cheung, CM; Yao, YZ; Brennan, FE; Fuller, PJ.
Characterization of the zebrafish (Danio rerio) mineralocorticoid receptor.
Mol Cell Endocrinol. 2011; 332(1-2):58-66
Doi: 10.1016/j.mce.2010.09.014
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Pippal Jyotsna Brijesh
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- Abstract:
- Comparison between evolutionarily distant receptors can provide critical insights into both structure and function. Sequence comparison between the mineralocorticoid receptors (MR) of the zebrafish (zMR) and human (hMR) reveals a high degree of sequence conservation in the major functional domains. We isolated a zMR cDNA to contrast the transcriptional response to a range of ligands and to establish whether a teleost MR exhibits the amino/carboxyl-terminal interaction (N/C-interaction) previously reported for the hMR. Aldosterone, deoxycorticosterone (DOC) and cortisol induced zMR transcriptional activity with similar efficacy to that observed with the hMR. The hMR antagonist, spironolactone, acted as an agonist with the zMR. The zMR exhibited an N/C-interaction in response to aldosterone but, in contrast to the hMR, cortisol and DOC predominantly stimulated the interaction in the zMR. Conservation of the N/C-interaction between evolutionarily distant MR provides evidence of functional significance.
- Find related publications in this database (using NLM MeSH Indexing)
- Aldosterone - metabolism Aldosterone - pharmacology
- Amino Acid Sequence -
- Animals -
- Antihypertensive Agents - metabolism Antihypertensive Agents - pharmacology
- Cell Line -
- Desoxycorticosterone - metabolism Desoxycorticosterone - pharmacology
- Humans -
- Hydrocortisone - metabolism Hydrocortisone - pharmacology
- Mineralocorticoid Receptor Antagonists - metabolism Mineralocorticoid Receptor Antagonists - pharmacology
- Molecular Sequence Data -
- Nimodipine - metabolism Nimodipine - pharmacology
- Receptors, Mineralocorticoid - agonists Receptors, Mineralocorticoid - genetics Receptors, Mineralocorticoid - metabolism
- Sequence Alignment -
- Sequence Analysis, DNA -
- Spironolactone - metabolism Spironolactone - pharmacology
- Transcriptional Activation - drug effects
- Zebrafish - anatomy & histology Zebrafish - genetics Zebrafish - metabolism
- Find related publications in this database (Keywords)
- Ligand-binding
- Deoxycorticosterone
- Aldosterone
- Receptor