Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pippal, JB; Fuller, PJ.
Structure-function relationships in the mineralocorticoid receptor.
J Mol Endocrinol. 2008; 41(6):405-413
Doi: 10.1677/JME-08-0093
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- Führende Autor*innen der Med Uni Graz
- Pippal Jyotsna Brijesh
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- Abstract:
- The signature action of aldosterone in the regulation of electrolyte and fluid balance is well established. However, the role of aldosterone as an important contributor to morbidity and mortality in heart failure has gained a heightened interest in recent years, but the mechanisms of this action are not well understood. Aldosterone is the principal physiological ligand for the mineralocorticoid receptor (MR), a ligand-activated transcription factor, that also binds to the physiological glucocorticoid, cortisol. Both classes of hormones bind with similar affinity to the MR, but the molecular basis of selective and tissue-specific effects of MR ligands is not yet fully documented. The structural and functional determinants of MR function are described and their significance is discussed.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Humans -
- Receptors, Mineralocorticoid - chemistry Receptors, Mineralocorticoid - genetics Receptors, Mineralocorticoid - metabolism Receptors, Mineralocorticoid - physiology
- Structure-Activity Relationship -