Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Chajes, V; Mahon, M; Kostner, GM.
Influence of LDL oxidation on the proliferation of human breast cancer cells.
Free Radic Biol Med. 1996; 20(1):113-120
Doi: 10.1016%2F0891-5849http://dx.doi.org/10.1016%2F0891-5849%2895%2902013-6
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- Co-Autor*innen der Med Uni Graz
- Kostner Gerhard
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- Abstract:
- The effects of lipid peroxidation and the antioxidant vitamin E contained in LDL isolated from control plasma (LDL--) and from plasma preincubated with 0.5 mmol/ml alpha-tocopherol (LDL+) on the proliferation of estrogen-receptor positive (ER+ : ZR-75, T-47-D, MCF-7) and negative (ER--: HBL-100, MDA-MB-231) human breast cancer cells were studied. Human skin fibroblasts served as controls. Incubation of plasma with 0.5 mmol/ml alpha-tocopherol resulted in a 3-fold increase of its content and a significant reduction in lipid hydroperoxides and conjugated dienes in LDL. Incubation of fibroblasts or ER+ tumor cells with LDL- or LDL+ had an effect on neither cell proliferation nor on the cellular levels of peroxidation products as compared to control incubations in the absence of LDL. In ER- cells, however, LDL+ stimulated the proliferation, whereas LDL- yielded a cytotoxic effect. Moreover, LDL- supplementation resulted in an increase in the content of hydroperoxides and conjugated dienes. LDL+ supplemented cells exhibited hydroperoxide levels in these tumor cells comparable to the basal levels measured in the absence of LDL. Our data suggested that peroxidation products in LDL are cytotoxic to estrogen-receptor negative breast tumor cells and vitamin E counteracts this effect.
- Find related publications in this database (using NLM MeSH Indexing)
- Breast Neoplasms - metabolism
- Cell Division - drug effects
- Cell Survival - drug effects
- Fibroblasts - drug effects
- Humans - drug effects
- Lipid Peroxidation - physiology
- Lipid Peroxides - metabolism
- Lipoproteins, LDL - pharmacology
- Receptors, Estrogen - metabolism
- Tumor Cells, Cultured - metabolism
- Vitamin E - pharmacology
- Find related publications in this database (Keywords)
- Breast Cancer
- Cell Proliferation
- Lipid Hydroperoxides
- Low Density Lipoproteins
- LDL-Receptor
- Vitamin-E
- Free Radicals