Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hammer, HF.
An update on pancreatic pathophysiology (do we have to rewrite pancreatic pathophysiology?).
Wien Med Wochenschr. 2014; 164(3-4):57-62
Doi: 10.1007/s10354-013-0260-y
PubMed
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- Führende Autor*innen der Med Uni Graz
- Hammer Heinz
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- Abstract:
- This review focuses on seven aspects of physiology and pathophysiology of the exocrine pancreas that have been intensively discussed and studied within the past few years: (1) the role of neurohormonal mechanisms like melatonin, leptin, or ghrelin in the stimulation of pancreatic enzyme secretion; (2) the initiation processes of acute pancreatitis, like fusion of zymogen granules with lysosomes leading to intracellular activation of trypsinogen by the lysosomal enzyme cathepsin B, or autoactivation of trypsinogen; (3) the role of genes in the pathogenesis of acute pancreatitis; (4) the role of alcohol and constituents of alcoholic beverages in the pathogenesis of acute pancreatitis; (5) the role of pancreatic hypertension, neuropathy, and central mechanisms for the pathogenesis of pain in chronic pancreatitis; (6) the relation between exocrine pancreatic function and diabetes mellitus; and (7) pathophysiology, diagnosis and treatment of pancreatic steatorrhea.
- Find related publications in this database (using NLM MeSH Indexing)
- Cathepsin B - physiology
- DNA Mutational Analysis -
- Diabetes Mellitus - genetics Diabetes Mellitus - physiopathology
- Ghrelin - physiology
- Leptin - physiology
- Melatonin - physiology
- Pancreas - physiopathology
- Pancreatic Juice - secretion
- Pancreatitis, Acute Necrotizing - genetics Pancreatitis, Acute Necrotizing - physiopathology
- Pancreatitis, Alcoholic - genetics Pancreatitis, Alcoholic - physiopathology
- Pancreatitis, Chronic - genetics Pancreatitis, Chronic - physiopathology
- Trypsinogen - metabolism