Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Weger, M; Steinbrugger, I; Haas, A; März, W; El-Shabrawi, Y; Weger, W; Schmut, O; Renner, W.
Role of the interleukin-6 -174 G>C gene polymorphism in retinal artery occlusion.
STROKE. 2005; 36(2): 249-252.
Doi: 10.1161/01.STR.0000151329.84830.37
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- Leading authors Med Uni Graz
- Renner Wilfried
- Weger Martin
- Co-authors Med Uni Graz
- El-Shabrawi Yosuf
- Haas Anton
- März Winfried
- Schmut Otto
- Steinbrugger Iris
- Weger Wolfgang
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- Abstract:
- BACKGROUND AND PURPOSE: Proinflammatory cytokines including interleukin-6 (IL-6) are supposed to play a pivotal role in the development of atherosclerosis. A common polymorphism in the promoter of the IL-6 gene (IL-6 -174G>C) affects plasma IL-6 concentrations and has been suggested as a risk factor for cardiovascular disease. The aim of the present case-control study was to investigate the role of this polymorphism for retinal artery occlusion (RAO). METHODS: One hundred eighty-two patients with RAO and 307 control subjects were genotyped for the IL-6 -174G>C polymorphism. Genotypes were determined by fluorogenic exonuclease (TaqMan) assay. RESULTS: The prevalence of the CC genotype was significantly lower in patients with RAO than in control subjects (10.4% versus 19.9%; P=0.006). Homozygosity for the C allele was associated with an odds ratio of 0.50 (95% CI, 0.28 to 0.89) for RAO. CONCLUSIONS: The CC genotype of the IL-6 -174G>C polymorphism may be associated with a protective effect against RAO.
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- Find related publications in this database (Keywords)
- atherosclerosis
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- retinal artery occlusion
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