Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Siamwala, JH; Majumder, S; Tamilarasan, KP; Muley, A; Reddy, SH; Kolluru, GK; Sinha, S; Chatterjee, S.
Simulated microgravity promotes nitric oxide-supported angiogenesis via the iNOS-cGMP-PKG pathway in macrovascular endothelial cells.
FEBS Lett. 2010; 584(15): 3415-3423.
Doi: 10.1016/j.febslet.2010.06.039
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- Co-authors Med Uni Graz
- Kuppusamy Palaniappan Tamilarasan
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- Abstract:
- Angiogenesis is a physiological process involving the growth of blood vessel in response to specific stimuli. The present study shows that limited microgravity treatments induce angiogenesis by activating macrovascular endothelial cells. Inhibition of nitric oxide production using pharmacological inhibitors and inducible nitric oxide synthase (iNOS) small interfering ribo nucleic acid (siRNA) abrogated microgravity induced nitric oxide production in macrovascular cells. The study further delineates that iNOS acts as a molecular switch for the heterogeneous effects of microgravity on macrovascular, endocardial and microvascular endothelial cells. Further dissection of nitric oxide downstream signaling confirms that simulated microgravity induces angiogenesis via the cyclic guanosine monophosphate (cGMP)-PKG dependent pathway.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Cattle -
- Cell Movement -
- Cell Proliferation -
- Chickens -
- Cyclic GMP - metabolism
- Cyclic GMP-Dependent Protein Kinases - metabolism
- Endothelial Cells - cytology Endothelial Cells - enzymology
- Humans -
- Neovascularization, Physiologic -
- Nitric Oxide - metabolism
- Nitric Oxide Synthase Type II - metabolism
- Nitric Oxide Synthase Type III - metabolism
- Signal Transduction -
- Sus scrofa -
- Weightlessness -
- Weightlessness Simulation -
- Wound Healing -
- Find related publications in this database (Keywords)
- Angiogenesis
- Microgravity
- iNOS
- Nitric oxide
- Endothelial cell