Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Baghdasaryan, A; Chiba, P; Trauner, M.
Clinical application of transcriptional activators of bile salt transporters.
Mol Aspects Med. 2014; 37:57-76
Doi: 10.1016/j.mam.2013.12.001
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- Führende Autor*innen der Med Uni Graz
- Baghdasaryan Anna
- Trauner Michael
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- Abstract:
- Hepatobiliary bile salt (BS) transporters are critical determinants of BS homeostasis controlling intracellular concentrations of BSs and their enterohepatic circulation. Genetic or acquired dysfunction of specific transport systems causes intrahepatic and systemic retention of potentially cytotoxic BSs, which, in high concentrations, may disturb integrity of cell membranes and subcellular organelles resulting in cell death, inflammation and fibrosis. Transcriptional regulation of canalicular BS efflux through bile salt export pump (BSEP), basolateral elimination through organic solute transporters alpha and beta (OSTα/OSTβ) as well as inhibition of hepatocellular BS uptake through basolateral Na(+)-taurocholate cotransporting polypeptide (NTCP) represent critical steps in protection from hepatocellular BS overload and can be targeted therapeutically. In this article, we review the potential clinical implications of the major BS transporters BSEP, OSTα/OSTβ and NTCP in the pathogenesis of hereditary and acquired cholestatic syndromes, provide an overview on transcriptional control of these transporters by the key regulatory nuclear receptors and discuss the potential therapeutic role of novel transcriptional activators of BS transporters in cholestasis. Copyright © 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism
- Bile Acids and Salts - metabolism
- Biological Transport -
- Cholestasis - genetics Cholestasis - pathology Cholestasis - therapy
- Gene Expression Regulation -
- Humans -
- Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism
- Organic Anion Transporters, Sodium-Dependent - genetics Organic Anion Transporters, Sodium-Dependent - metabolism
- Symporters - genetics Symporters - metabolism
- Transcriptional Activation - genetics
- Find related publications in this database (Keywords)
- Nuclear receptors
- ATB-binding cassette transporters
- Cholestasis