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SHR Neuro Cancer Cardio Lipid Metab Microb

De Guio, F; Reyes, S; Duering, M; Pirpamer, L; Chabriat, H; Jouvent, E.
Decreased T1 contrast between gray matter and normal-appearing white matter in CADASIL.
AJNR Am J Neuroradiol. 2014; 35(1):72-76 Doi: 10.3174/ajnr.A3639 [OPEN ACCESS]
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Co-authors Med Uni Graz: Pirpamer Lukas
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Abstract:: CADASIL is the most frequent hereditary small-vessel disease of the brain. The clinical impact of various MR imaging markers has been repeatedly studied in this disorder, but alterations of contrast between gray matter and normal-appearing white matter remain unknown. The aim of this study was to evaluate the contrast alterations between gray matter and normal-appearing white matter on T1-weighted images in patients with CADASIL compared with healthy subjects. Contrast between gray matter and normal-appearing white matter was assessed by using histogram analyses of 3D T1 high-resolution MR imaging in 23 patients with CADASIL at the initial stage of the disease (Mini-Mental State Examination score > 24 and modified Rankin scale score ≤ 1; mean age, 53.5 ± 11.1 years) and 30 age- and sex-matched controls. T1 contrast between gray matter and normal-appearing white matter was significantly reduced in patients compared with age- and sex-matched controls (patients: 1.35 ± 0.08 versus controls: 1.43 ± 0.04, P < 10(-5)). This reduction was mainly driven by a signal decrease in normal-appearing white matter. Contrast loss was strongly related to the volume of white matter hyperintensities. Conventional 3D T1 imaging shows significant loss of contrast between gray matter and normal-appearing white matter in CADASIL. This probably reflects tissue changes in normal-appearing white matter outside signal abnormalities on T2 or FLAIR sequences. These contrast alterations should be taken into account for image interpretation and postprocessing.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Aged -; Brain - pathology; CADASIL - pathology; Female -; Humans -; Magnetic Resonance Imaging - methods; Male -; Middle Aged -; Nerve Fibers, Myelinated - pathology; Neurons - pathology