Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Fickert, P; Ramschak, H; Kenner, L; Hoefler, G; Hinterleitner, TA; Petritsch, W; Klimpfinger, M; Krejs, GJ; Stauber, RE.
Acute Budd-Chiari syndrome with fulminant hepatic failure in a pregnant woman with factor V Leiden mutation.
Gastroenterology. 1996; 111(6):1670-1673
Doi: 10.1016/S0016-5085(96)70031-8
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Fickert Peter
- Co-Autor*innen der Med Uni Graz
- Hinterleitner Thomas
- Höfler Gerald
- Kenner Lukas
- Krejs Günter Josef
- Petritsch Wolfgang
- Stauber Rudolf
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- Abstract:
- Budd-Chiari syndrome during pregnancy has rarely been reported. This report presents a case of acute hepatic failure in a 20-year-old pregnant woman attributable to Budd-Chiari syndrome with underlying resistance to activated protein C caused by factor V Leiden mutation. The patient delivered a healthy girl by cesarean section in the 31st week of pregnancy. Acute hepatic failure in the 6th week postpartum was successfully treated by emergency liver transplantation, and the patient and her child were doing well at 8-month follow-up. Liver transplantation was lifesaving; normal factor V production by the transplant corrected the underlying coagulopathy. In this patient, latent thrombophilia attributable to activated protein C resistance was apparently aggravated by the hypercoagulable state of pregnancy leading to acute Budd-Chiari syndrome. Activated protein C resistance should be sought as an etiologic factor in patients with Budd-Chiari syndrome.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Budd-Chiari Syndrome - blood Budd-Chiari Syndrome - etiology
- Factor V - genetics
- Female -
- Humans -
- Liver Failure - etiology Liver Failure - therapy
- Liver Transplantation -
- Mutation -
- Pregnancy -
- Pregnancy Complications, Cardiovascular - blood