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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Nardone, R; De Blasi, P; Höller, Y; Christova, M; Tezzon, F; Trinka, E; Brigo, F.
Repetitive transcranial magnetic stimulation transiently reduces punding in Parkinson's disease: a preliminary study.
J Neural Transm (Vienna). 2014; 121(3):267-274
Doi: 10.1007/s00702-013-1100-3
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- Co-authors Med Uni Graz
- Christova Monica
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- Abstract:
- Amongst the impulse-control disorders (ICDs) associated with dopamine-replacement therapy in patients with Parkinson's disease (PD) is a repetitive, complex, stereotyped behaviour called punding. Disruption of the reciprocal loops between the striatum and structures in the prefrontal cortex (PFC) following dopamine depletion may predispose patients with PD to these behavioural disorders. The purpose of the present study was to assess the effects of repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral PFC (DLPFC) on punding in PD. We used low-frequency (LF) rTMS in four PD patients presenting with punding. Punding was transiently reversed by LF-rTMS over the DLPFC without enhancing motor impairment. The effect was more sustained after right DLPFC rTMS. Therefore, LF-rTMS produced a transient beneficial effect in PD patients with punding, similar to that reported in PD patients with levodopa-induced dyskinesias. rTMS might have therapeutic potential for the treatment of punding and perhaps other ICDs in PD.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Disruptive, Impulse Control, and Conduct Disorders - etiology
- Disruptive, Impulse Control, and Conduct Disorders - therapy
- Double-Blind Method -
- Female -
- Humans -
- Male -
- Middle Aged -
- Parkinson Disease - complications
- Parkinson Disease - therapy
- Psychiatric Status Rating Scales -
- Severity of Illness Index -
- Statistics, Nonparametric -
- Time Factors -
- Transcranial Magnetic Stimulation - methods
- Find related publications in this database (Keywords)
- Parkinson's disease
- Punding
- Impulse control disorders
- Repetitive transcranial magnetic stimulation
- Dorsolateral prefrontal cortex