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Gisondi, P; Cazzaniga, S; Chimenti, S; Giannetti, A; Maccarone, M; Picardo, M; Girolomoni, G; Naldi, L; Psocare Study Group.
Metabolic abnormalities associated with initiation of systemic treatment for psoriasis: evidence from the Italian Psocare Registry.
J Eur Acad Dermatol Venereol. 2013; 27(1):e30-e41 Doi: 10.1111/j.1468-3083.2012.04450.x
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Study Group Mitglieder der Med Uni Graz:: Brunasso Vernetti Alexandra Maria
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Abstract:: Objective To evaluate variations in laboratory parameters and diagnoses of selected clinical conditions up to 16 weeks after starting a new systemic psoriasis treatment for Psocare Registry enrollees. Design Prospective cohort study. Setting Italian public referral centres for psoriasis treatment. Patients First-time recipients (n = 10,539) of continuous systemic psoriasis treatment for at least 16 weeks. Main outcome measure Mean variations in (weeks 8 and 16) and proportions of patients reaching a clinically meaningful increase in serum levels (week 16) of total and low-density lipoprotein cholesterol, triglycerides, aspartate amino transferase, alanine amino transferase and creatinine, as well as week-16 cumulative incidences of new diagnoses of diabetes mellitus and arterial hypertension. Results Mean cholesterol and triglyceride levels significantly increased in patients treated with acitretin or cyclosporine. Mean triglyceride levels also increased in efalizumab- and etanercept-treated patients. Mean transaminase values increased in methotrexate-treated patients, and mean aspartate amino transferase levels increased in infliximab-treated patients. The average serum creatinine value increased in cyclosporine-treated patients. Acitretin and cyclosporine were associated with risk of hypercholesterolaemia (odds ratios 1.51 and 1.34) and acitretin with risk of hypertriglyceridaemia (odds ratio 1.43). Methotrexate and infliximab were associated with risk of more than doubling the upper normal aspartate amino transferase (odds ratios 2.06 and 1.87) and alanine amino transferase (odds ratios 2.38 and 1.74) values. The relative risk of developing arterial hypertension and diabetes was increased for patients receiving cyclosporine (odds ratios 3.31 and 2.88). Conclusion Systemic treatments for psoriasis resulted in heterogeneous effects on the parameters analysed.
Find related publications in this database (using NLM MeSH Indexing): Adolescent -; Adult -; Age Distribution -; Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - adverse effects; Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects; Cohort Studies -; Dose-Response Relationship, Drug -; Drug Administration Schedule -; Evidence-Based Medicine -; Female -; Humans -; Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - adverse effects; Incidence -; Incidence -; Male -; Metabolic Diseases - chemically induced Metabolic Diseases - epidemiology Metabolic Diseases - physiopathology; Prospective Studies -; Psoriasis - diagnosis Psoriasis - drug therapy; Registries -; Risk Assessment -; Severity of Illness Index -; Sex Distribution -; Treatment Outcome -; Young Adult -