Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Shinde, SS; Forman, MR; Kuerer, HM; Yan, K; Peintinger, F; Hunt, KK; Hortobagyi, GN; Pusztai, L; Symmans, WF.
Higher parity and shorter breastfeeding duration: association with triple-negative phenotype of breast cancer.
Cancer. 2010; 116(21): 4933-4943.
Doi: 10.1002/cncr.25443
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- Peintinger Florentia
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- Abstract:
- BACKGROUND: The combination of increased parity and shorter breastfeeding duration might increase the odds of the least differentiated triple-negative breast cancer (BC) phenotype, theoretically because an expanded progenitor cell population from each pregnancy would incompletely differentiate postpartum. METHODS: Subjects consisted of a consecutive case series of 2473 women treated for invasive breast cancer between 2001 and 2006. Breast cancer phenotype (triple-negative BC, vs non-triple-negative BC) was compared with reproductive and demographic information. Odds ratios (OR) with 95% confidence intervals (CIs) for the association of breastfeeding duration (months per child) and parity with triple-negative BC were calculated after adjusting for ethnicity, age at menarche, family history, and age at diagnosis. RESULTS: Compared with non-triple-negative BC, triple-negative BC was associated with shorter duration of breastfeeding per child (OR, 0.93; 95% CI, 0.90-0.97) and with higher parity (OR, 1.12; 95% CI, 1.06-1.20) By using multivariate logistic regression, triple-negative BC was independently associated with higher parity (OR, 2.76 [95% CI, 1.86-4.08] if >= 3 live births; OR, 1.89 [95% CI, 1.30-2.74] if <= 2 live births vs nulliparae), breastfeeding duration (OR, 0.55 [95% CI, 0.41-0.74] if >2 mo/child and OR, 0.58 [95% CI, 0.42-0.82] if <= 2 mo/child vs none), African American ethnicity (OR, 2.10; 95% CI, 1.52-2.92), and younger age at diagnosis (OR, 3.02 [95% CI, 2.03-4.47] if <= 40 years vs >60 years). CONCLUSIONS: Among women with invasive breast cancer, higher parity and the absence or short duration of breastfeeding were independently associated with triple-negative BC. Any duration of breastfeeding was found to be associated with lower probability of triple-negative BC, and the odds of this phenotype decreased with increasing duration of breastfeeding. Cancer 2010;116:4933-43. (C) 2010 American Cancer Society.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Age Factors -
- Aged -
- Aged, 80 and over -
- Breast Feeding -
- Breast Neoplasms - ethnology Breast Neoplasms - etiology
- Female -
- Humans -
- Menarche -
- Middle Aged -
- Neoplasms, Hormone-Dependent - ethnology Neoplasms, Hormone-Dependent - etiology Neoplasms, Hormone-Dependent - genetics
- Parity -
- Phenotype -
- Pregnancy -
- Risk Factors -
- Time Factors -
- Find related publications in this database (Keywords)
- breast cancer
- triple-negative
- breastfeeding
- lactation
- parity
- ethnicity
- progenitor