Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Dawood, S; Gonzalez-Angulo, AM; Peintinger, F; Broglio, K; Symmans, WF; Kau, SW; Islam, R; Hortobagyi, GN; Buzdar, AU.
Efficacy and safety of neoadjuvant trastuzumab combined with paclitaxel and epirubicin: a retrospective review of the M. D. Anderson experience.
Cancer. 2007; 110(6): 1195-1200.
Doi: 10.1002/cncr.22895
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- Co-Autor*innen der Med Uni Graz
- Peintinger Florentia
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- Abstract:
- BACKGROUND. A previously published prospective randomized phase 3 trial showed that administration of 24 weeks of primary systemic chemotherapy (PST) with paclitaxel and FEC75 (fluorouracil, epirubicin, cyclophosphamide) concurrently with trastuzumab in patients with HER2-positive primary breast cancer resulted in a 60% pathologic complete response rate (PCR) with no associated severe cardiac toxicity. The purpose of this study was to review the efficacy and safety of a similar regimen outside the setting of a clinical trial. METHODS. Patients with HER2-positive breast cancer (defined as either immunohistochemical 3+ or fluorescence in situ hybridization-positive) that had received 24 weeks of neoadjuvant trastuzumab concurrently with taxane and anthracycline-based chemotherapy between 2004 and 2006 were included in the analysis. PST chemotherapy consisted of paclitaxel (80 mg/m(2)) weekly for 12 weeks followed by 4 cycles of FEC75 (500 mg/m(2), 75 mg/m(2), and 500 mg/m(2), respectively). RESULTS. Forty patients were identified. The median age was 48 years (range, 2981). In all, 60% of patients had stage III disease and 4 had inflammatory breast cancer. The PCR rate was 55% (95% confidence interval [CI], 38.5%-70.7%). At a median follow-up of 19 months. 5 patients had a recurrence, of which 4 did not achieve a PCR. No severe cardiac events were observed. CONCLUSIONS. Stage II and III HER2-positive breast cancer patients achieved a high rate of PCR with trastuzumab given concurrently with paclitaxel and FEC75 chemotherapy. No severe cardiac events were observed with the regimen. The data concur with the results of a previously published trial.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Antibodies, Monoclonal - administration & dosage
- Antibodies, Monoclonal, Humanized -
- Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use
- Breast Neoplasms - chemistry Breast Neoplasms - drug therapy
- Chemotherapy, Adjuvant -
- Epirubicin - administration & dosage
- Female -
- Humans -
- In Situ Hybridization, Fluorescence -
- Middle Aged -
- Neoadjuvant Therapy - methods
- Paclitaxel - administration & dosage
- Receptor, erbB-2 - analysis
- Retrospective Studies -
- Retrospective Studies -
- Treatment Outcome -
- Tumor Markers, Biological - analysis
- Find related publications in this database (Keywords)
- trastummab
- paclitaxel
- epirubicin
- neoadjuvant