Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Reitsamer, R; Peintinger, F; Prokop, E; Menzel, C; Cimpoca, W; Rettenbacher, L.
Sentinel lymph node biopsy alone without axillary lymph node dissection--follow up of sentinel lymph node negative breast cancer patients.
Eur J Surg Oncol. 2003; 29(3):221-223
Doi: 10.1053/ejso.2002.1320
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Peintinger Florentia
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- Abstract:
- Aims: To evaluate the rate of axillary recurrences in sentinel lymph node (SLN) negative breast cancer patients after sentinel lymph node biopsy (SLNB) alone without further axillary lymph node dissection (ALND). Methods: Between May 1999 and February 2001 all patients who had primary invasive breast cancer and were SLN negative were eligible for this prospective study. SLNB was performed by using the combined method with radioactive tracer and blue dye. SLNs were examined by frozen section, standard H/E staining and immunohistochemistry staining. SLN negative patients did not receive further ALND. Follow-up was done three-monthly with clinical controls, blood samples and ultrasound of the breast and axilla. An annual mammogram was performed. Results: 116 patients with T I or T2 invasive breast cancer were included in this trial. All 116 patients had negative SLNs in frozen sections, in H/E staining and in immunohistochemistry staining. The mean number of removed SLNs was 2.03 +/- 1.22. Mean tumor size was 17.15 +/- 7.62 mm. Postmenopausal patients totalled 79.3 and 20.7% of patients were premenopausal. No local or axillary recurrences occurred at a mean duration of follow-up of 22.12 +/- 6.38 months. Conclusion: The absence of axillary recurrences after SLNB without ALND in SLN negative breast cancer patients supports the hypothesis that SLNB is accurate and safe while providing less surgical morbidity. Short term results are very promising. SLNB without ALND in SLN negative patients is an excellent procedure for axillary staging in a cohort of breast cancer patients with small tumors. (C) 2002 Elsevier Science Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Axilla - pathology
- Breast Neoplasms - pathology Breast Neoplasms - surgery
- Female -
- Follow-Up Studies -
- Humans -
- Lymphatic Metastasis - pathology
- Middle Aged -
- Neoplasm Invasiveness -
- Neoplasm Recurrence, Local -
- Neoplasm Staging -
- Prospective Studies -
- Sentinel Lymph Node Biopsy -
- Find related publications in this database (Keywords)
- sentinel lymph node biopsy
- axillary lymph node dissection
- breast cancer
- axillary staging