Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Reitsamer, R; Peintinger, F; Sedlmayer, F; Kopp, M; Menzel, C; Cimpoca, W; Glueck, S; Rahim, H; Kopp, P; Deutschmann, H; Merz, F; Brandis, M; Kogelnik, H.
Intraoperative radiotherapy given as a boost after breast-conserving surgery in breast cancer patients.
Eur J Cancer. 2002; 38(12):1607-1610
Doi: 10.1016/S0959-8049(02)00116-8
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Deutschmann Hannes
- Peintinger Florentia
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Conventional radiotherapy after breast-conserving therapy is confined to 50-55 Gy external beam radiation therapy (EBRT) to the whole breast and 10-16 Gy external boost radiation to the tumour bed or brachytherapy to the tumour bed. Local recurrence rate after breast-conserving surgery varies between 5 and 18%. External boost radiation can partially miss the tumour bed and therefore can result in local failure. Intra-operative radiotherapy (IORT) as a high precision boost can prevent a 'geographical miss'. From October 1998 to December 2000, 156 patients with stage I and stage II breast cancer were operated upon in a dedicated IORT facility. After local excision of the tumour, the tumour bed was temporarily approximated by sutures to bring the tissue in the radiation planning target volume. A single dose of 9 Gy was applied to the 90% reference isodose with energies ranging from 4 to 15 MeV, using round applicator tubes 4-8 cm in diameter. After wound healing, the patients received additional 51-56 Gy EBRT to the whole breast. No acute complications associated with IORT were observed. In 5 patients, a secondary mastectomy had to be performed because of tumour multicentricity in the final pathological report or excessive intraductal component. 2 patients developed rib necroses. In 7 patients, wound healing problems occurred. After a mean follow-up of 18 months, no local recurrences were observed. Cosmesis of the breast was very good and comparable to patients without IORT. Preliminary data suggest that IORT given as a boost after breast-conserving surgery could be a reliable alternative to conventional postoperative fractionated boost radiation by accurate dose delivery and avoiding geographical misses, by enabling smaller treatment volumes and complete skin-sparing and by reducing postoperative radiation time by 7-14 days.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Breast Neoplasms - radiotherapy Breast Neoplasms - surgery
- Carcinoma, Ductal, Breast - radiotherapy Carcinoma, Ductal, Breast - surgery
- Combined Modality Therapy -
- Female -
- Humans -
- Intraoperative Care - methods
- Mastectomy, Segmental - methods
- Middle Aged -
- Neoplasm Recurrence, Local - prevention & control
- Prospective Studies -
- Treatment Outcome -
- Find related publications in this database (Keywords)
- breast cancer
- breast-conserving surgery
- intraoperative radiotherapy
- boost radiation