Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Gamillscheg, A; Urban, C; Slavc, I; Lackner, H; Hauer, C.
Infections in the neutropenic phase following bone marrow transplantation: comparison of laminar airflow isolation with conventional isolation
Wien Klin Wochenschr. 1991; 103(3):82-87
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Gamillscheg Andreas
- Co-Autor*innen der Med Uni Graz
- Hauer Almuthe
- Lackner Herwig
- Urban Ernst-Christian
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- Abstract:
- From May 1978 to September 1989 45 patients underwent 25 allogeneic and 21 autologous bone marrow transplantations (BMT) and 1 peripheral stem cell transplantation for the following indications: severe aplastic anemia (n = 4), hematological malignancies (n = 28), malignant solid tumours (n = 12) and sideroblastic anemia (n = 1). The first group of 20 patients was isolated in a conventional hospital room, while management of the aplastic phase in the second group of 25 patients was performed in a laminar air flow (LAF) unit. All patients received total decontamination. In a retrospective analysis the number of positive blood cultures during the neutropenic period was 85% in the first group, as compared with 40% in the second group, and the number of febrile episodes was 85% versus 64%, respectively. Despite the fact that the septic morbidity was lower in the LAF group, mortality during the neutropenic period (15% in group I versus 16% in group II) was unaffected and survival rate (45% in group I versus 36% in group II) did not improve. We conclude that LAF protection will only have a positive impact on survival rate if the incidence of non-infectious complications of BMT, such as organ toxicity or graft-versus-host disease, is likewise reduced.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Bone Marrow Transplantation - immunology
- Child - immunology
- Child, Preschool - immunology
- Cross Infection - prevention and control
- Environment, Controlled - prevention and control
- Female - prevention and control
- Humans - prevention and control
- Immune Tolerance - immunology
- Infant - immunology
- Male - immunology
- Neutropenia - complications
- Opportunistic Infections - immunology
- Patient Isolation - methods
- Postoperative Complications - immunology
- Find related publications in this database (Keywords)
- Bone Marrow Transplantation
- Infections
- Laminar Air Flow Isolation