Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pecks, U; Rath, W; Caspers, R; Sosnowsky, K; Ziems, B; Thiesen, HJ; Maass, N; Huppertz, B.
Oxidatively modified LDL particles in the human placenta in early and late onset intrauterine growth restriction.
Placenta. 2013; 34(12):1142-1149
Doi: 10.1016/j.placenta.2013.10.006
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Huppertz Berthold
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- Abstract:
- Reduced serum LDL concentrations have been observed in pregnancies complicated by intrauterine growth restriction (IUGR) as compared to healthy pregnant women. Since increased oxidative stress has been suggested to play a major role in IUGR we now hypothesized that the lower LDL concentrations are accompanied by an accumulation of oxidized LDLs in the placenta. Fifteen placentas of near term and preterm born IUGR, and a gestational age matched control group (CTRL n = 15) were analyzed. Placental minimal modified LDL and fully oxidized LDL particles were measured by ELISA, and by immunohistochemistry, and were related to maternal and fetal serum lipid profiles. We found fully oxidized LDL but not minimal modified LDL being increased in the preterm subgroup of IUGR (n = 10) as compared to preterm CTRL (n = 10; p < 0.05). An increased staining intensity of trophoblasts in preterm IUGR subjects as compared to preterm CTRL has been confirmed by immunohistochemistry (p < 0.05). No difference could be found between the term groups (n = 5 each). Correlation analysis revealed an inverse relationship of maternal LDL (ρ = −0.49, p = 0.03) and fetal HDL cholesterol (ρ = −0.46, p = 0.04) with placental fully oxidized LDL particle concentration within preterms. IUGR is a heterogeneous entity. Different pathomechanisms seem to underlie the disease in preterm and term subjects with oxidation of LDL within the placenta possibly taking place in preterm IUGRs. We conclude that the reduced maternal LDL cholesterol concentration in IUGR pregnancies is attributed to increased accumulation of oxidized LDL particles within the placenta at least in early onset IUGR
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Cesarean Section -
- Cholesterol, HDL - blood
- Cohort Studies -
- Female -
- Fetal Development -
- Fetal Growth Retardation - metabolism
- Humans -
- Infant, Newborn -
- Lipoproteins, LDL - blood
- Male -
- Oligohydramnios - etiology
- Oxidative Stress -
- Placenta - metabolism
- Placentation -
- Pre-Eclampsia - diagnosis
- Pregnancy -
- Premature Birth -
- Prenatal Diagnosis -
- Severity of Illness Index -
- Up-Regulation -
- Young Adult -
- Find related publications in this database (Keywords)
- Placenta
- LDL
- Oxidized LDL
- Oxidative stress
- Intrauterine growth restriction