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SHR Neuro Cancer Cardio Lipid Metab Microb
Fried, I; Artl, M; Cota, C; Müller, H; Bartolo, E; Boi, S; Chiarelli, C; Vale, E; Schmuth, M; Wiesner, T; Speicher, MR; Cerroni, L.
Clinicopathologic and molecular features in cutaneous extranodal natural killer-/T-cell lymphoma, nasal type, with aggressive and indolent course.
J Am Acad Dermatol. 2014; 70(4):716-723
Doi: 10.1016/j.jaad.2013.11.028
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Cerroni Lorenzo
- Fried Isabella
- Co-authors Med Uni Graz
- Speicher Michael
- Wiesner Thomas
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- Abstract:
- Extranodal natural killer-/T-cell lymphoma, nasal type (ENKTCL-NT) is a highly aggressive lymphoma and prognosis is usually poor. The genetic background of primary cutaneous cases is poorly understood. We sought to evaluate the clinicopathologic features of cutaneous ENKTCL-NT, and the prognostic significance of genomic copy number alterations. Eight cases of cutaneous ENKTCL-NT (5 primary, 2 secondary, 1 no staging performed), including 2 patients with an unusually prolonged course of 5 and 23 years, were investigated using array comparative genomic hybridization. All patients presented with typical clinicopathologic features. Epstein-Barr virus was found in neoplastic cells in all specimens. Copy number alterations were detected in all 8 cases with losses on 6q (37.5% of cases) and 7p (37.5% of cases), and gains on 7q (37.5% of cases) being the most frequent. Complexity of array comparative genomic hybridization profile did not correlate with the course of the disease. However, an increase of copy number alterations was detected in sequential biopsy specimens of 1 long-term survivor. This was a small case series retrospective study. Clinicopathologic features of cutaneous ENKTCL-NT are distinctive. Lower number of copy number alterations cannot be used as predictor for prolonged survival in cutaneous ENKTCL-NT. Copyright © 2013 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged, 80 and over -
- Biopsy, Needle -
- Female -
- Gene Expression Regulation, Neoplastic -
- Genetic Predisposition to Disease - epidemiology
- Humans -
- Immunohistochemistry -
- In Situ Hybridization -
- Killer Cells, Natural - pathology
- Lymphoma, T-Cell, Cutaneous - genetics Lymphoma, T-Cell, Cutaneous - mortality Lymphoma, T-Cell, Cutaneous - pathology
- Male -
- Middle Aged -
- Nose Neoplasms - genetics Nose Neoplasms - mortality Nose Neoplasms - pathology
- Poly(A)-Binding Proteins - genetics
- Predictive Value of Tests -
- Retrospective Studies -
- Risk Assessment -
- Sampling Studies -
- Survival Analysis -
- Find related publications in this database (Keywords)
- array comparative genomic hybridization
- clinicopathologic features
- cutaneous T-cell lymphoma
- extranodal natural killer-/T-cell lymphoma
- nasal type
- genomic aberrations
- prognosis