Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lam, UD; Lerchbaum, E; Schweighofer, N; Trummer, O; Eberhard, K; Genser, B; Pieber, TR; Obermayer-Pietsch, B.
Association of MEP1A gene variants with insulin metabolism in central European women with polycystic ovary syndrome.
Gene. 2014; 537(2):245-252
Doi: 10.1016/j.gene.2013.12.055
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Lam Uyen Do Phuong
- Co-Autor*innen der Med Uni Graz
- Eberhard Katharina
- Lerchbaum Elisabeth
- Obermayer-Pietsch Barbara
- Pieber Thomas
- Schweighofer Natascha
- Trummer Olivia
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- Abstract:
- Polycystic ovary syndrome (PCOS) shows not only hyperandrogenemia, hirsutism and fertility problems, but also metabolic disturbances including obesity, cardiovascular events and type-2 diabetes. Accumulating evidence suggests some degree of inflammation associated with prominent aspects of PCOS. We aimed to investigate the association of genetic variants 3'UTR rs17468190 (G/T) of the inflammation-associated gene MEP1A (GenBank ID: NM_005588.2) with metabolic disturbances in PCOS and healthy control women. Genetic variants rs17468190 (G/T) of MEP1A gene were analyzed in 576 PCOS women and 206 controls by using the Taqman fluorogenic 5'-exonuclease assay. This polymorphism was tested for association with anthropometric, metabolic, hormonal, and functional parameters of PCOS. There was a borderline significant difference in genotype distribution between PCOS and control women (p=0.046). In overweight/obese PCOS patients, the variants rs17468190 (G/T) in the MEP1A gene are associated with glucose and insulin metabolism. In a dominant model, the GG genotype of the MEP1A gene was more strongly associated with insulin metabolism in overweight/obese PCOS women (body mass index, BMI>25 kg/m(2)), than in GT+TT genotypes. The MEP1A GG-carriers showed a significantly increased homeostatic model assessment - insulin resistance (HOMA-IR) (p=0.003), elevation of fasting insulin (p=0.004) and stimulated insulin (30 min, p<0.001; 60 min, p=0.009; 120 min, p=0.009) as well as triglyceride (p=0.032) levels. MEP1A is a possible target gene for disease modification in PCOS. It might contribute to the abnormalities of glucose metabolism and insulin sensitivity and serve as a diagnostic or therapeutic target gene for PCOS. Copyright © 2014 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- 3' Untranslated Regions -
- Adult -
- Adult -
- Body Mass Index -
- Case-Control Studies -
- European Continental Ancestry Group - genetics
- Female -
- Gene Frequency -
- Genetic Predisposition to Disease -
- Glucose - metabolism
- Humans -
- Insulin - genetics
- Insulin - metabolism
- Insulin Resistance - genetics
- Metalloendopeptidases - genetics
- Metalloendopeptidases - metabolism
- Obesity - complications
- Obesity - genetics
- Obesity - metabolism
- Overweight - genetics
- Overweight - metabolism
- Polycystic Ovary Syndrome - complications
- Polycystic Ovary Syndrome - genetics
- Polycystic Ovary Syndrome - metabolism
- Polymorphism, Single Nucleotide -
- Triglycerides - blood
- Triglycerides - genetics
- Find related publications in this database (Keywords)
- PCOS
- Meprin 1A
- Obesity
- Polymorphism
- Lipids
- Metabolic