Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Tomaschitz, A; Meinitzer, A; Pilz, S; Rus-Machan, J; Genser, B; Drechsler, C; Grammer, T; Krane, V; Ritz, E; Kleber, ME; Pieske, B; Kraigher-Krainer, E; Fahrleitner-Pammer, A; Wanner, C; Boehm, BO; März, W.
Homoarginine, kidney function and cardiovascular mortality risk.
Nephrol Dial Transplant. 2014; 29(3):663-671
Doi: 10.1093/ndt/gft512
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Tomaschitz Andreas
- Co-Autor*innen der Med Uni Graz
- Fahrleitner-Pammer Astrid
- Kraigher-Krainer Elisabeth
- März Winfried
- Meinitzer Andreas
- Pieske Burkert Mathias
- Pilz Stefan
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Homoarginine is a novel biomarker for cardiovascular diseases. In the present large cohort study, we evaluate how homoarginine is linked to kidney function and examine the potential interaction of homoarginine and kidney function as predictors of cardiovascular outcomes. Serum homoarginine (mean: 2.41 ± 1.05 µmol/L), cystatin C and creatinine-based estimated GFR (eGFR, mean: 86.2 ± 23.0 mL/min per 1.73 m(2)) were measured in 3037 patients (mean age: 62.8 ± 10.6 years; 31.5% women) who were referred to coronary angiography. Homoarginine was positively associated with eGFR (age- and gender-adjusted partial correlation coefficient: 0.20, P < 0.001); using multiple regression analysis, eGFR emerged as an independent predictor of serum homoarginine (β = 0.10, SE 0.01, P < 0.001). Overall cardiovascular mortality was 18.5% (563 cardiovascular deaths) after 9.9 years. Multivariate Cox proportional hazard analysis revealed that compared with participants in the highest gender-specific homoarginine tertile, those in the lowest tertile were at increased risk of cardiovascular death [multivariate-adjusted HR 1.47; 95% confidence interval (95% CI) 1.15-1.87, P = 0.002]. After adjustment for confounders, both homoarginine and eGFR were associated independently with cardiovascular mortality, with a strong synergistic interaction (P for interaction 0.005). After stratifying the cohort into persons with eGFRs <60 and ≥60 mL/min per 1.73 m(2), there was a stronger association between homoarginine and cardiovascular mortality in patients within eGFR below 60 (mean: 46.5 ± 12.0 mL/min per 1.73 m(2); HR per log SD increment of homoarginine 0.78; 95% CI 0.65-0.95, P = 0.013) compared to those with eGFR values ≥60 mL/min per 1.73 m(2). Subgroup analysis revealed that homoarginine is exclusively associated with death due to heart failure in subjects with eGFR values <60 mL/min per 1.73 m(2) (HR per log SD 0.56; 95% CI 0.37-0.85; P = 0.006). Low homoarginine is strongly related to decreased kidney function, adverse cardiovascular events and death due to heart failure. The relationship between low homoarginine and adverse cardiovascular outcomes is most obvious when kidney function is impaired.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Biomarkers - blood
- Cohort Studies -
- Female -
- Glomerular Filtration Rate -
- Heart Failure - blood
- Heart Failure - etiology
- Heart Failure - mortality
- Homoarginine - blood
- Humans -
- Kidney Diseases - blood
- Kidney Diseases - complications
- Kidney Diseases - mortality
- Male -
- Middle Aged -
- Mortality -
- Proportional Hazards Models -
- Risk Factors -
- Find related publications in this database (Keywords)
- cardiovascular mortality
- homoarginine
- kidney function