Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Kálai, T; Borza, E; Antus, C; Radnai, B; Gulyás-Fekete, G; Fehér, A; Sümegi, B; Hideg, K.
Synthesis and study of new paramagnetic resveratrol analogues.
Bioorg Med Chem. 2011; 19(24):7311-7317
Doi: 10.1016/j.bmc.2011.10.066
Web of Science
PubMed
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FullText_MUG
- Co-authors Med Uni Graz
- Radnai Balazs
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- Abstract:
- New resveratrol analogues containing five- and six-membered nitroxides and isoindoline nitroxides were synthesized. These new compounds were compared to resveratrol based on their ABTS radical scavenging ability as well on their capacity to suppress inflammatory process in macrophages induced by lipopolysaccharides. The ABTS and ROS scavenging activities of new molecules were the same or weaker than that of resveratrol, but some of paramagnetic resveratrol derivatives suppressed nitrite and TNFα production more efficiently than resveratrol. Based on these results the new nitroxide and phenol containing hybrid molecules can be considered as new antioxidant and anti-inflammatory agents.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Anti-Inflammatory Agents - chemical synthesis
- Benzothiazoles - metabolism
- Cell Line -
- Free Radical Scavengers - chemical synthesis
- Lipopolysaccharides - immunology
- Macrophages - drug effects
- Mice -
- Reactive Oxygen Species - metabolism
- Stilbenes - chemical synthesis
- Sulfonic Acids - metabolism
- Tumor Necrosis Factor-alpha - immunology
- Find related publications in this database (Keywords)
- Antioxidants
- Anti-inflammatory agents
- Free radicals
- Pd-catalysed reactions
- Resveratrol