Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Rieken, M; Kluth, LA; Xylinas, E; Seitz, C; Fajkovic, H; Karakiewicz, PI; Lotan, Y; Briganti, A; Loidl, W; Faison, T; Crivelli, JJ; Scherr, DS; Bachmann, A; Tewari, AK; Kautzky-Willer, A; Pummer, K; Shariat, SF.
Impact of statin use on biochemical recurrence in patients treated with radical prostatectomy.
Prostate Cancer Prostatic Dis. 2013; 16(4):367-371
Doi: 10.1038/pcan.2013.31
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Pummer Karl
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The impact of statin use on biochemical recurrence (BCR) in patients treated with radical prostatectomy (RP) remains controversial. We retrospectively evaluated 6842 patients who underwent RP for clinically localized prostate cancer (PC) between 2000 and 2011. Uni- and multivariable cox regression models addressed the association of statin use with BCR. Overall, 2275 (33.3%) patients used statins. Statin users were older and had a higher rate of positive surgical margins than patients not using statins (P-values 0.05). Within a median follow-up of 25 months (interquartile range: 8-42 months), 778 (11.4%) patients experienced BCR. Actuarial estimate 5-years BCR-free survival was 82%±1 for patients without statin use and 84±1% for patients using statins (P=0.05); statin use was not associated with BCR (hazard ratio: 0.88, 95% confidence interval: 0.76-1.03, P=0.10) after adjusting for the effects of standard clinicopathologic features. In PC patients undergoing RP, statin use was not independently associated with lower risk of BCR.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Humans -
- Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects
- Male -
- Middle Aged -
- Neoplasm Recurrence, Local -
- Proportional Hazards Models -
- Prostate-Specific Antigen - blood
- Prostatectomy -
- Prostatic Neoplasms - metabolism
- Retrospective Studies -
- Find related publications in this database (Keywords)
- statins
- radical prostatectomy
- biochemical recurrence