Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Rostásy, K; Mader, S; Hennes, EM; Schanda, K; Gredler, V; Guenther, A; Blaschek, A; Korenke, C; Pritsch, M; Pohl, D; Maier, O; Kuchukhidze, G; Brunner-Krainz, M; Berger, T; Reindl, M.
Persisting myelin oligodendrocyte glycoprotein antibodies in aquaporin-4 antibody negative pediatric neuromyelitis optica.
Mult Scler. 2013; 19(8):1052-1059
Doi: 10.1177/1352458512470310
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Brunner-Krainz Michaela
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- Abstract:
- Background:Recently we showed that antibodies to myelin oligodendrocyte glycoprotein (MOG) can be found in aquaporin-4 (AQP4)-immunoglobulin (IgG) seronegative pediatric and adult patients with definite and high-risk neuromyelitis optica (NMO). Objective:The purpose of this study was to describe the clinical characteristics and temporal dynamics of MOG-IgG in AQP4-IgG seronegative pediatric patients presenting with definite NMO. Methods:Children with definite NMO who were referred for further testing of serum antibodies for AQP4 and MOG with a cell-based assay were included in this study. Clinical disease course, cerebrospinal fluid and magnetic resonance imaging (MRI) studies of these patients were reviewed. Results:Between 2008 and 2012 eight children who fulfilled the diagnostic criteria of definite NMO were recruited. Two children with definite NMO tested positive for AQP4-IgG but were negative for MOG-IgG antibodies. Three children had an absence of AQP4-IgG and MOG-IgG antibodies. Three children with definite NMO had high titers of serum MOG-IgG antibodies (1: 160), but no AQP4-directed humoral immune response. Longitudinal analysis of serum samples of the latter three children showed persisting high MOG-IgG titers over time. Conclusion:Pediatric patients presenting with clinical symptoms and MRI findings highly suggestive of NMO but with high and persisting MOG-IgG antibody titers are most likely to represent a distinct subgroup of acute demyelinating diseases with important clinical and therapeutic implications.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aquaporin 4 - immunology
- Autoantibodies - blood
- Autoantigens - immunology
- Child -
- Female -
- Humans -
- Immunoglobulin G - immunology
- Magnetic Resonance Imaging -
- Male -
- Myelin-Oligodendrocyte Glycoprotein - immunology
- Neuromyelitis Optica - blood
- Find related publications in this database (Keywords)
- Neuromyelitis optica
- children
- MOG antibodies
- optic neuritis
- AQP-4 antibodies