Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pihlstrøm, H; Mjøen, G; März, W; Olav Dahle, D; Abedini, S; Holme, I; Fellström, B; Jardine, A; Pilz, S; Holdaaas, H.
Neopterin is associated with cardiovascular events and all-cause mortality in renal transplant patients.
Clin Transplant. 2014; 28(1):111-119
Doi: 10.1111/ctr.12285
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- Co-Autor*innen der Med Uni Graz
- März Winfried
- Pilz Stefan
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- Abstract:
- Inflammatory markers show significant associations with cardiovascular events and all-cause mortality after kidney transplantation. Neopterin, reflecting interferon-γ-release, may better reflect the proinflammatory state of recipients than less specific markers. Kidney transplant recipients in the Assessment of LEscol in Renal Transplant (ALERT) trial were examined and investigated for an association between serum neopterin and subsequent clinical events: graft loss, major cardiovascular events (MACE) and all-cause mortality. After adjustment for established and emerging risk factors neopterin expressed as neopterin-to-creatinine ratio was significantly associated with MACE (p = 0.009) and all-cause mortality (p = 0.002). Endpoints were more frequent with increasing quartiles of neopterin-to-creatinine ratio. The incidence rates of MACE and all-cause mortality were significantly increased in the upper quartiles compared with the first. This long-term prospective analysis in stable kidney allograft recipients suggests that neopterin is associated with long-term risk of cardiovascular events and all-cause mortality, but not renal outcomes. © 2013 The Authors Clinical Transplantation Published by John Wiley & Sons Ltd.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Biomarkers - blood
- Cardiovascular Diseases - blood
- Cardiovascular Diseases - etiology
- Cardiovascular Diseases - mortality
- Cause of Death -
- Creatinine - blood
- Double-Blind Method -
- Female -
- Follow-Up Studies -
- Glomerular Filtration Rate -
- Graft Rejection - blood
- Graft Rejection - etiology
- Graft Rejection - mortality
- Humans -
- Kidney Failure, Chronic - blood
- Kidney Failure, Chronic - surgery
- Kidney Function Tests -
- Kidney Transplantation -
- Male -
- Middle Aged -
- Neopterin - blood
- Postoperative Complications - blood
- Postoperative Complications - etiology
- Postoperative Complications - mortality
- Prognosis -
- Prospective Studies -
- Risk Factors -
- Survival Rate -
- Find related publications in this database (Keywords)
- inflammatory marker
- kidney transplantation
- long-term
- neopterin
- outcomes