Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Špoljarić, IV; Lopar, M; Koller, M; Muhr, A; Salerno, A; Reiterer, A; Malli, K; Angerer, H; Strohmeier, K; Schober, S; Mittelbach, M; Horvat, P.
Mathematical modeling of poly[(R)-3-hydroxyalkanoate] synthesis by Cupriavidus necator DSM 545 on substrates stemming from biodiesel production.
Bioresour Technol. 2013; 133(5-6): 482-494.
Doi: 10.1016/j.biortech.2013.01.126
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Angerer Hannes
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- Abstract:
- Two low structured mathematical models for fed-batch production of polyhydroxybutyrate and poly[hydroxybutyrate-co-hydroxyvalerate] by Cupriavidus necator DSM 545 on renewable substrates (glycerol and fatty acid methyl esters-FAME) combined with glucose and valeric acid, were established. The models were used for development/optimization of feeding strategies of carbon and nitrogen sources concerning PHA content and polymer/copolymer composition. Glycerol/glucose fermentation featured a max. specific growth rate of 0.171 h(-1), a max. specific production rate of 0.038 h(-1) and a PHB content of 64.5%, whereas the FAME/valeric acid fermentation resulted in a max. specific growth rate of 0.046 h(-1), a max. specific production rate of 0.07 h(-1) and 63.6% PHBV content with 4.3% of 3-hydroxyvalerate (3HV) in PHBV. A strong inhibition of glycerol consumption by glucose was confirmed (inhibition constant ki,G=4.28×10(-4) g L(-1)). Applied concentration of FAME (10-12 g L(-1)) positively influenced on PHBV synthesis. HV/PHBV ratio depends on applied VA concentration.
- Find related publications in this database (using NLM MeSH Indexing)
- Batch Cell Culture Techniques -
- Biofuels - microbiology
- Computer Simulation -
- Cupriavidus necator - drug effects
- Esters - pharmacology
- Fermentation - drug effects
- Glucose - pharmacology
- Glycerol - pharmacology
- Kinetics -
- Metabolic Networks and Pathways -
- Models, Biological -
- Nitrogen - pharmacology
- Pentanoic Acids - pharmacology
- Polyhydroxyalkanoates - biosynthesis
- Reproducibility of Results -
- Find related publications in this database (Keywords)
- Cupriavidus necator
- Biodiesel
- Polyhydroxybutyrate (PHB)
- Poly[hydroxybutyrate-co-hydroxyvalerate] (PHBV)
- Mathematical modeling