Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Stauber, RE; Mischinger, HJ; Trauner, M; Pristautz, H.
Indications for liver transplantation in neoplasms of the liver.
Acta Med Austriaca. 1993; 20(3):57-60
Web of Science
PubMed
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Stauber Rudolf
- Co-Autor*innen der Med Uni Graz
- Mischinger Hans-Jörg
- Trauner Michael
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- Abstract:
- Orthotopic liver transplantation for hepatic neoplasms is controversial. In the past, liver transplantation was utilized to treat various advanced hepatic neoplasms such as hepatocellular carcinoma including the fibrolamellar variant, cholangiocellular carcinoma, epithelioid hemangio-endothelioma, and liver metastases. In many cases, total hepatectomy with orthotopic liver replacement is the only treatment option with intent to cure because of reduced liver function in cirrhotic patients limiting resectability. On the other hand, results of transplantation are poor; for hepatocellular carcinoma, the 5-year-survival probability averages only 20%. Thus, hepatic neoplasms have to compete with benign liver diseases for a limited supply of donor organs. However, success rates of liver transplantation were higher for fibrolamellar carcinoma and for epithelioid hemangioendothelioma. New treatment strategies for hepatocellular carcinoma including neoadjuvant chemotherapy and chemoembolization are currently being investigated. Results of liver transplantation for cholangiocellular carcinoma or hepatic metastases have been disappointing. Single cases have been successfully treated with the "cluster operation" designed by Starzl in 1988.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenoma, Bile Duct - mortality Adenoma, Bile Duct - pathology Adenoma, Bile Duct - surgery
- Bile Duct Neoplasms - mortality Bile Duct Neoplasms - pathology Bile Duct Neoplasms - surgery
- Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery
- Follow-Up Studies -
- Hemangioendothelioma - mortality Hemangioendothelioma - pathology Hemangioendothelioma - surgery
- Hepatectomy -
- Humans -
- Liver Neoplasms - mortality Liver Neoplasms - pathology Liver Neoplasms - secondary Liver Neoplasms - surgery
- Liver Transplantation -
- Neoplasm Staging -
- Postoperative Complications - mortality
- Survival Rate -
- Find related publications in this database (Keywords)
- Orthotopic Liver Transplantation
- Hepatic Neoplasms
- Hepatocellular Carcinoma
- Fibrolamellar Carcinoma