Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Berger, CE; Marteau, R; Pabinger, C; Kröner, A; Ogris, E; Engel, A.
Decreased cutaneous vitamin D-synthesis in heavily melanized individuals: a rare cause for pathologic fractures of the hip.
Wien Klin Wochenschr. 2003; 115(5-6):186-190
Doi: 10.1007/BF03040308
(- Case Report)
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Pabinger Christoph
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- Abstract:
- Painful pathological fractures of the femoral neck and the subtrochanteric region of the femur are reported in two women originating from India. After exclusion of renal or intestinal causes, laboratory data on bone metabolism, scintigraphic and radiographic examinations were characteristic for the presence of secondary hyperparathyroidism. Based on vitamin deficiency and low calcium absorption, disturbed mineralization of bone and increased osteoclastic resorption have apparently led to osteomalacia and subsequent fracturing. Fracture localization necessitated surgical fixation in one patient; conservative treatment including protected weightbearing was effective in the other women. After supplementation of calcium and vitamin D3, levels of parathyroid hormone and scintigraphic alterations returned to normal in both patients. In these two cases, pathological fractures of the hip could be attributed to the presence of secondary hyperparathyroidism based on decreased cutaneous vitamin D synthesis.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Adult -
- Bone Density - physiology
- Developing Countries -
- Diagnostic Imaging -
- Female -
- Femoral Neck Fractures - diagnosis Femoral Neck Fractures - etiology Femoral Neck Fractures - physiopathology
- Fractures, Spontaneous - diagnosis Fractures, Spontaneous - etiology Fractures, Spontaneous - physiopathology
- Hip Fractures - diagnosis Hip Fractures - etiology Hip Fractures - physiopathology
- Humans -
- Hyperparathyroidism, Secondary - diagnosis Hyperparathyroidism, Secondary - etiology Hyperparathyroidism, Secondary - physiopathology
- Hyperparathyroidism, Secondary - ethnology
- Magnetic Resonance Imaging -
- Middle Aged -
- Osteomalacia - diagnosis Osteomalacia - etiology Osteomalacia - physiopathology
- Pregnancy -
- Pregnancy Complications - etiology Pregnancy Complications - physiopathology Pregnancy Complications - radiography
- Risk Factors -
- Skin - metabolism
- Skin Pigmentation - physiology
- Vitamin D - biosynthesis
- Find related publications in this database (Keywords)
- pathological fracture
- hip
- secondary hyperparathyroidism
- vitamin D
- cutaneous synthesis