Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hafner, F; Haas, E; Belaj, K; Froehlich, H; Gary, T; Eller, P; Brodmann, M.
Endothelial function and carotid intima-media thickness in giant-cell arteritis.
Eur J Clin Invest. 2014; 44(3):249-256
Doi: 10.1111/eci.12227
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Hafner Franz
- Co-Autor*innen der Med Uni Graz
- Belaj Klara
- Brodmann Marianne
- Eller Philipp
- Fröhlich Harald
- Gary Thomas
- Haas Elke
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- Abstract:
- Vascular endothelial dysfunction and intima-media thickness are characteristic aspects of several vasculitides. We investigated retrospectively the impact of steroid treatment on endothelial dysfunction and intima-media thickness in giant-cell arteritis. Forty-one patients with giant-cell arteritis (28 female and 13 male) underwent flow-mediated dilatation, a marker of endothelial function, and carotid intima-media thickness within 24 h after diagnosis and 6 months thereafter. Both parameters were investigated in 41 patients of an age- and gender-matched control group. Brachial flow-mediated dilatation response at baseline was 3.4% (0.2, 8.0) and 1.7% (0.2, 4.8) in giant-cell arteritis patients and control group, respectively. After 6 months treatment, flow-mediated dilatation response was 2.8% (0.4, 4.8) in patients with giant-cell arteritis (P = 0.066) and 1.4% (0.1, 5.5) in the control group (P = 0.741). In contrast, mean carotid intima-media thickness of giant-cell arteritis patients improved significantly between baseline [1.0 mm (0.79, 1.2)] and 6-month follow-up [0.82 mm (0.7, 1.04), P < 0.001]. Subjects with additional symptoms of polymyalgia rheumatica had a notable enlargement of carotid intima-media thickness [1.23 mm (1.14, 2.09)] compared to giant-cell arteritis patients without polymyalgia rheumatica at baseline [0.91 mm (0.76, 1.04), P = 0.001] and 6-month follow-up [1.16 mm (0.80, 1.26) vs. 0.77 mm (0.68, 0.88), P = 0.009]. Steroid therapy has no influence on endothelial function but does significantly improve carotid intima-media thickness in giant-cell arteritis. This divergence of endothelial function and intima-media thickness reflects the specifity of giant-cell arteritis for cerebrovascular arteries thereby sparing the brachial arteries. © 2013 Stichting European Society for Clinical Investigation Journal Foundation.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Anti-Inflammatory Agents - therapeutic use
- Blood Flow Velocity -
- Brachial Artery - diagnostic imaging
- Brachial Artery - physiopathology
- Carotid Arteries - diagnostic imaging
- Carotid Arteries - physiopathology
- Carotid Intima-Media Thickness -
- Case-Control Studies -
- Endothelium, Vascular - diagnostic imaging
- Endothelium, Vascular - physiopathology
- Female -
- Giant Cell Arteritis - complications
- Giant Cell Arteritis - diagnostic imaging
- Giant Cell Arteritis - drug therapy
- Humans -
- Male -
- Polymyalgia Rheumatica - complications
- Polymyalgia Rheumatica - diagnostic imaging
- Polymyalgia Rheumatica - drug therapy
- Prednisone - therapeutic use
- Retrospective Studies -
- Find related publications in this database (Keywords)
- Arteriosclerosis
- Giant-cell arteritis
- polymyalgia rheumatica
- sonography
- vasculitis