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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Fügl, A; Gasser, H; Watzak, G; Bucher, A; Feierfeil, J; Jürgens, G; Watzek, G; Hallström, S; Gruber, R.
S-nitroso albumin enhances bone formation in a rabbit calvaria model.
Int J Oral Maxillofac Surg. 2014; 43(3):381-386
Doi: 10.1016/j.ijom.2013.06.018
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Hallström Seth
- Co-authors Med Uni Graz
- Jürgens Günther
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- Abstract:
- Nitric oxide (NO) is a mediator involved in bone regeneration. We therefore examined the effect of the novel NO donor, S-nitroso human serum albumin (S-NO-HSA) on bone formation in a rabbit calvaria augmentation model. Circular grooves (8 mm diameter, two per animal) were created by a trephine drill in the cortical bone of 40 rabbits and titanium caps were placed on the rabbit calvaria bone filled with a collagen sponge soaked with either 100 μL S-NO-HSA (5%, 20%) or human albumin (5%, 20%). After 4 weeks the titanium hemispheres were subjected to histological and histomorphometric analysis. Bone formation and the volume of the residual collagen sponge were evaluated. S-NO-HSA treatment groups had a significantly higher volume of newly formed bone underneath the titanium hemispheres compared to the albumin control groups (5%: 15.5 ± 4.0% versus 10.6 ± 2.9%; P < 0.05; 20%: 14.0 ± 4.6% versus 6.0 ± 3.8%; P < 0.01). The volume of residual collagen sponge was also significantly lower in the S-NO-HSA groups compared to the control groups (5%: 0.4 ± 0.5% versus 2.6 ± 2.4%; P < 0.05 and 20%: 1.5 ± 2.7% versus 13.0 ± 18.7%; P < 0.01). This study demonstrates for the first time that S-NO-HSA promotes bone formation by slow NO release. Additionally, S-NO-HSA increases collagen sponge degradation. Copyright © 2013 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Bone Regeneration - drug effects
- Collagen - pharmacology
- Male -
- Nitroso Compounds - pharmacology
- Rabbits -
- Serum Albumin, Bovine - pharmacology
- Skull - drug effects
- Skull - surgery
- Find related publications in this database (Keywords)
- nitric oxide
- bone regeneration
- rabbit
- augmentation
- guided bone regeneration