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Machann, W; Geier, O; Koeppe, S; O'Donnell, T; Greiser, A; Breunig, F; Sandstede, J; Hahn, D; Koestler, H; Beer, M.
Reproducibility of manual and semi-automated late enhancement quantification in patients with Fabry disease.
Acta Radiol. 2014; 55(2):155-160
Doi: 10.1177/0284185113505275
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Beer Meinrad
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- Abstract:
- Late enhancement (LE) imaging is increasingly used for diagnosis of non-ischemic cardiomyopathy. However, the mostly patchy appearance of LE in this context may reduce the reproducibility of LE measurement. To report intra- and inter-observer variabilities of LE measurements in Fabry disease using manual and semi-automated quantification. Twenty MRI data-sets of male patients aged 44 ± 7 years were analyzed twice (interval 12 months) by one observer and additionally once by a second observer. Left ventricular (LV) parameters were determined using cine MRI. Gradient-echo LE images were analyzed by manual planimetry and by a semi-automatic prototype software. Variabilities were determined by Bland-Altman analyses and additionally intra-class correlation coefficient (ICC) values were calculated to survey intra- and inter-observer reproducibility. The amount of LE was 5.2 ± 5.1 mL or 2.8 ± 2.6 % of LV mass (observer 2). LE was detected predominantly intramurally in a patchy pattern. All patients had LE restricted to the basal infero-lateral parts of the LV. The extent of LE correlated to LV mass (207 ± 70 g, P < 0.05, r = 0.6). The intra- and inter-observer variabilities were -0.6 to 1.0 mL and -0.7 to 1.6 mL, respectively (95% confidence intervals). ICC values were 0.981-0.999. The semi-automatic software allowed quantification of LE areas in all patients. The comparison of LE amount determined by semi-automatic software versus manual planimetry yielded an intra-observer variability ranging from -1.9 to 2.3 mL. Semi-automatic planimetry of patchy LE in patients with Fabry disease is feasible. The determined intra- and inter-observer variabilities for manual and semi-automatic planimetry were in the range of 20-40% of LE amount with high ICC values.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Cardiomyopathies - pathology
- Cohort Studies -
- Fabry Disease - pathology
- Heart Ventricles -
- Humans -
- Image Enhancement -
- Magnetic Resonance Imaging -
- Male -
- Middle Aged -
- Observer Variation -
- Reproducibility of Results -
- Find related publications in this database (Keywords)
- Cardiomyopathy
- late enhancement
- reproducibility
- quantification