Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Tuder, RM; Stacher, E; Robinson, J; Kumar, R; Graham, BB.
Pathology of pulmonary hypertension.
Clin Chest Med. 2013; 34(4):639-650
Doi: 10.1016/j.ccm.2013.08.009
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- Co-Autor*innen der Med Uni Graz
- Stacher-Priehse Elvira
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- Abstract:
- The pathology of pulmonary hypertension includes numerous abnormalities of the intima, media, and adventitia of the pulmonary vascular tree. A recently completed systematic analysis revealed high variability of morphologic measurements within a given pulmonary arterial hypertension (PAH) lung and among all PAH lungs, as well as distinct pathologic subphenotypes, and included a subset of lungs lacking intimal and medial remodeling. There was correlation between perivascular inflammation, remodeling, and hemodynamics. This article summarizes the pathologic features of the normal and abnormal pulmonary circulation, and correlations with animal models.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Disease Models, Animal -
- Hemodynamics -
- Humans -
- Hypertension, Pulmonary - pathology
- Inflammation - pathology
- Lung - blood supply
- Find related publications in this database (Keywords)
- Pulmonary hypertension
- Smooth muscle cells
- Endothelial cells
- Angiogenesis
- Vascular remodeling