Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lallas, A; Tzellos, T; Kyrgidis, A; Apalla, Z; Zalaudek, I; Karatolias, A; Ferrara, G; Piana, S; Longo, C; Moscarella, E; Stratigos, A; Argenziano, G.
Accuracy of dermoscopic criteria for discriminating superficial from other subtypes of basal cell carcinoma.
J Am Acad Dermatol. 2014; 70(2):303-311
Doi: 10.1016/j.jaad.2013.10.003
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Zalaudek Iris
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- Abstract:
- The management of basal cell carcinoma (BCC) depends, among other factors, on its histopathologic subtype. Although dermoscopic criteria of BCC have been investigated, the possible role of dermoscopy in predicting the tumor subtype remains unclear. We sought to assess the diagnostic accuracy of dermoscopic criteria for differentiating superficial BCC (sBCC) from other BCC subtypes. Dermoscopic images of histopathologically confirmed BCCs were retrospectively evaluated for the presence of predefined criteria. Univariate and adjusted odds ratios were calculated. Discriminant functions were used to plot receiver operating characteristic curves. In all, 77 sBCCs and 258 non-sBCCs were included. Maple leaf-like areas, short fine superficial telangiectasia, multiple small erosions, and shiny white-red structureless areas were potent predictors of sBCC, each making its diagnosis over 5-fold more likely. Conversely, the presence of arborizing vessels, blue-gray ovoid nests, and ulceration gave 11-fold, 15-fold, and 3-fold increased possibility for the diagnosis of non-sBCCs, respectively. Based on the results of the multivariate analysis, we propose a diagnostic algorithm that can predict the diagnosis of sBCC with a sensitivity of 81.9% and a specificity of 81.8%. The retrospective design and the inclusion of only Caucasian patients are limitations. Dermoscopy is reliable in differentiating sBCC from other BCC subtypes. Copyright © 2013 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Analysis of Variance -
- Biopsy, Needle -
- Carcinoma, Basal Cell - diagnosis
- Cohort Studies -
- Dermoscopy - methods
- Diagnosis, Differential -
- Female -
- Humans -
- Immunohistochemistry -
- Male -
- Middle Aged -
- Multivariate Analysis -
- Neoplasm Invasiveness - pathology
- Neoplasm Staging -
- Retrospective Studies -
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- Skin Neoplasms - diagnosis
- Find related publications in this database (Keywords)
- basal cell carcinoma
- dermoscopy
- diagnosis
- nodular basal cell carcinoma
- superficial basal cell carcinoma