Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pichler, K; Kraus, T; Martinelli, E; Sadoghi, P; Musumeci, G; Uggowitzer, PJ; Weinberg, AM.
Cellular reactions to biodegradable magnesium alloys on human growth plate chondrocytes and osteoblasts.
Int Orthop. 2014; 38(4):881-889
Doi: 10.1007/s00264-013-2163-3
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- Führende Autor*innen der Med Uni Graz
- Kraus Tanja
- Pichler Karin
- Co-Autor*innen der Med Uni Graz
- Martinelli Elisabeth
- Sadoghi Patrick
- Weinberg Annelie-Martina
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- Abstract:
- In recent decades operative fracture treatment using elastic stable intramedullary nails (ESINs) has mainly taken precedence over conservative alternatives in children. The development of biodegradable materials that could be used for ESINs would be a further step towards treatment improvement. Due to its mechanical and elastic properties, magnesium seems to be an ideal material for biodegradable implant application. The aim of this study was therefore to investigate the cellular reaction to biodegradable magnesium implants in vitro. Primary human growth plate chondrocytes and MG63 osteoblasts were used for this study. Viability and metabolic activity in response to the eluate of a rapidly and a slower degrading magnesium alloy were investigated. Furthermore, changes in gene expression were assessed and live cell imaging was performed. A superior performance of the slower degrading WZ21 alloy's eluate was detected regarding cell viability and metabolic activity, cell proliferation and morphology. However, the ZX50 alloy's eluate induced a favourable up-regulation of osteogenic markers in MG63 osteoblasts. This study showed that magnesium alloys for use in biodegradable implant application are well tolerated in both osteoblasts and growth plate chondrocytes respectively.
- Find related publications in this database (using NLM MeSH Indexing)
- Absorbable Implants -
- Alloys - chemistry Alloys - pharmacology
- Cell Line -
- Chondrocytes -
- Growth Plate - cytology
- Humans -
- Magnesium - metabolism
- Materials Testing -
- Osteoblasts - drug effects
- Reverse Transcriptase Polymerase Chain Reaction -
- Surface Properties -
- Tensile Strength -
- Find related publications in this database (Keywords)
- Biodegradable magnesium
- Orthopaedics
- Immature skeleton
- Growth
- Biocompatibility