Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zimmermann, C; Weger, M; Faschinger, C; Renner, W; Mossböck, G.
Role of interleukin 6-174G>C polymorphism
in primary open-angle glaucoma.
Eur J Ophthalmol. 2012; 23(2):183-186
Doi: 10.5301/ejo.5000213
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Mossböck Georg
- Zimmermann-Roth Christina
- Co-Autor*innen der Med Uni Graz
- Faschinger Christoph
- Renner Wilfried
- Weger Martin
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- Abstract:
- PURPOSE. In addition to its proinflammatory effects, interleukin (IL)-6 also possesses antiapoptotic properties. Recently, IL-6 has been reported to protect retinal ganglion cells from pressure-induced apoptosis, indicating a possible role in the pathogenesis of primary open-angle glaucoma (POAG). A common polymorphism in the promoter region of IL-6 gene at position -174 characterized by a substitution from G to C has been found to decrease transcription rate of IL-6. The aim of our study was to investigate a hypothesized association between IL-6-174G>C polymorphism and POAG in Caucasian patients. METHODS. The present case-control study comprised 191 unrelated patients with POAG and 191 control subjects, matched for age and sex. Genotyping of the IL-6-174G>C polymorphism was done using polymerase chain reaction. RESULTS. Allelic frequencies and genotype distribution of IL-6-174G>C did not significantly differ between patients with POAG and control subjects (p>0.05). Presence of the IL-6-174C allele was associated with a nonsignificant odds ratio of 0.78 (95% confidence interval 0.46-1.32; p=0.78) for POAG. CONCLUSIONS. Our findings suggest that the functional IL-6-174G>C polymorphism itself is unlikely a major risk factor for POAG.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Case-Control Studies -
- Female -
- Gene Frequency -
- Genotype -
- Glaucoma, Open-Angle - genetics
- Humans -
- Interleukin-6 - genetics
- Intraocular Pressure -
- Male -
- Middle Aged -
- Polymerase Chain Reaction -
- Polymorphism, Single Nucleotide -
- Risk Factors -
- Tonometry, Ocular -
- Find related publications in this database (Keywords)
- Gene polymorphism
- Interleukin-6
- Primary open-angle glaucoma