Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Ferrara, G; Misciali, C; Brenn, T; Cerroni, L; Kazakov, DW; Perasole, A; Russo, R; Ricci, R; Crisman, G; Fanti, PA; Passarini, B; Patrizi, A.
The impact of molecular morphology techniques on the expert diagnosis in melanocytic skin neoplasms.
Int J Surg Pathol. 2013; 21(5):483-492
Doi: 10.1177/1066896913491323
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- Co-authors Med Uni Graz
- Cerroni Lorenzo
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- Abstract:
- Thirteen melanocytic skin neoplasms with a consultation diagnosis by A. Bernard Ackerman were submitted to immunohistochemistry for HMB-45, Ki67, cyclin D1, e-cadherin, and p16; 9/13 cases underwent fluorescence in situ hybridization (FISH) test targeting 6p25 (RREB1), 6q23 (MYB), centromere 6 (Cep6), and 11q13 (CCND1), as well as the centromere 7 (Cep7). A "consensus diagnosis" among 3 experts was also advocated both before and after morphomolecular information. Three neoplasms with a consultation diagnosis of Spitz nevus showed at least 3 abnormal immunohistochemical patterns; 2 of these cases were also FISH-positive for CCND1 gain, but none of them had a final consensus diagnosis of melanoma. Two neoplasms with a consultation diagnosis of congenital nevus received a consensus diagnosis of melanoma. Molecular morphology techniques can highlight the atypical features of melanocytic neoplasms and support existence of a morphobiologic "spectrum": This should be mirrored in the final report by abandoning the dichotomic (benign vs malignant) diagnostic approach.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Female -
- Humans -
- Immunohistochemistry -
- In Situ Hybridization, Fluorescence -
- Male -
- Melanoma - diagnosis
- Middle Aged -
- Nevus, Pigmented - diagnosis
- Skin Neoplasms - diagnosis
- Tumor Markers, Biological - analysis
- Find related publications in this database (Keywords)
- immunohistochemistry
- fluorescence in situ hybridization
- atypical nevus
- melanoma