Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
van Kaam, AH; De Jaegere, AP; Rimensberger, PC; Neovent Study Group.
Incidence of hypo- and hyper-capnia in a cross-sectional European cohort of ventilated newborn infants.
Arch Dis Child Fetal Neonatal Ed. 2013; 98(4): F323-F326.
Doi: 10.1136/archdischild-2012-302649
Web of Science
PubMed
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- Reiterer Friedrich
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- Abstract:
- Objective To determine the incidence of hypo- and hyper-capnia in a European cohort of ventilated newborn infants. Design and setting Two-point cross-sectional prospective study in 173 European neonatal intensive care units. Patients and methods Patient characteristics, ventilator settings and measurements, and blood gas analyses were collected for endotracheally ventilated newborn infants on two separate dates. Results A total of 1569 blood gas analyses were performed in 508 included patients with a mean +/- SD PCO2 of 48 +/- 12 mm Hg or 6.4 +/- 1.6 kPa (range 17-104 mm Hg or 2.3-13.9 kPa). Hypocapnia (PCO2< 30 mm Hg or 4 kPa) and hypercapnia (PCO2> 52 mm Hg or 7 kPa) was present in, respectively, 69 (4%) and 492 (31%) of the blood gases. Hypocapnia was most common in the first 3 days of life (7.3%) and hypercapnia after the first week of life (42.6%). PCO2 was significantly higher in preterm infants (49 mm Hg or 6.5 kPa) than term infants (43 mm Hg or 5.7 kPa) and significantly lower during pressure-limited ventilation (47 mm Hg or 6.3 +/- 1.6 kPa) compared with volume-targeted ventilation (51 mm Hg or 6.8 +/- 1.7 kPa) and high-frequency ventilation (50 mm Hg or 6.7 +/- 1.7 kPa). Conclusions This study shows that hypocapnia is a relatively uncommon finding during neonatal ventilation. The higher incidence of hypercapnia may suggest that permissive hypercapnia has found its way into daily clinical practice.
- Find related publications in this database (using NLM MeSH Indexing)
- Blood Gas Analysis -
- Carbon Dioxide - blood
- Cross-Sectional Studies -
- Cross-Sectional Studies - epidemiology
- European Continental Ancestry Group -
- Female -
- Humans -
- Hypercapnia - blood Hypercapnia - epidemiology
- Hypocapnia - blood Hypocapnia - epidemiology
- Incidence -
- Infant, Newborn -
- Infant, Premature -
- Infant, Premature, Diseases - epidemiology
- Intensive Care Units, Neonatal -
- Male -
- Prospective Studies -
- Ventilators, Mechanical -