Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hoenigl, M; Prattes, J; Drescher, M; Tovilo, K; Seeber, K; Kessler, HH; Vander, K; Palfner, M; Meilinger, M; Avian, A; Valentin, T; Zollner-Schwetz, I; Strenger, V; Krause, R; Flick, H.
Comparison of clinical presentation and laboratory values at admission between PCR-confirmed influenza A H1N1 infection and influenza-like disease, South-East Austria.
Infection. 2014; 42(2):317-324
Doi: 10.1007/s15010-013-0549-1
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Flick Holger
- Hönigl Martin
- Co-Autor*innen der Med Uni Graz
- Avian Alexander
- Kessler Harald
- Krause Robert
- Meilinger Michael
- Palfner Michael
- Prattes Jürgen
- Strenger Volker
- Valentin Thomas
- Zollner-Schwetz Ines
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- Abstract:
- Reliable and rapid diagnosis of influenza A H1N1 is essential to initiate the appropriate antiviral therapy and preventive measures. As PCR assays are time-consuming and rapid antigen tests have a limited sensitivity, official influenza case definitions are used in many clinical settings. These, however, are based exclusively on clinical criteria and have only a moderate potential to differentiate between influenza and other febrile diseases. Only limited data on the differences in clinical and laboratory parameters between influenza and non-influenza febrile diseases are available to date. This was a retrospective case-negative control series that was conducted in Styria, southeast Austria. We analyzed the differences in clinical presentation and laboratory admission parameters between patients with PCR-confirmed H1N1 influenza infection (n = 199) and those with influenza-like disease and negative influenza PCR results (ILD group; n = 252). In the multivariable analysis lower C-reactive protein (CRP) level, lower white blood cell (WBC) count, fever, wheezing, cough, and the absence of nausea or sudden onset remained significant predictors of H1N1 influenza in adult patients (n = 263). Lower CRP level, lower WBC count, and cough remained significant predictors in pediatric patients (<16 years; n = 188). Lower CRP level, lower WBC count, and cough were significant predictors of H1N1 in both the adult and pediatric patient group. These data may help to develop an improved case definition for suspected H1N1 infection which combines clinical findings and easily available laboratory parameters.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Aged, 80 and over -
- Case-Control Studies -
- Female -
- Hospitalization -
- Humans -
- Infant, Newborn -
- Influenza A Virus, H1N1 Subtype - isolation & purification
- Influenza, Human - virology
- Male -
- Multivariate Analysis -
- Polymerase Chain Reaction -
- Retrospective Studies -
- Young Adult -
- Find related publications in this database (Keywords)
- H1N1
- Influenza A
- Clinical presentation
- Prediction
- Laboratory values
- PCR