Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Valentin, A; Troppan, K; Pfeilstöcker, M; Nösslinger, T; Linkesch, W; Neumeister, P.
Safety and tolerability of intrathecal liposomal cytarabine as central nervous system prophylaxis in patients with acute lymphoblastic leukemia.
Leuk Lymphoma. 2014; 55(8):1739-1742
Doi: 10.3109/10428194.2013.853765
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Neumeister Peter
- Co-authors Med Uni Graz
- Linkesch Werner
- Prochazka Katharina
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- Abstract:
- Central nervous system recurrence in acute lymphoblastic leukemia (ALL) occurs in up to 15% of patients and is frequently associated with poor outcome. The purpose of our study was to evaluate the efficacy and safety of a slow-release liposomal formulation of cytarabine for intrathecal (IT) meningeal prophylaxis in patients suffering from ALL. Forty patients aged 20-77 years (median 36) were preventively treated with a total of 96 (range 1-6) single doses containing 50 mg of liposomal cytarabine on a compassionate use basis. After a median observation period of 23 months (range 2-118) only two patients experienced a combined medullary-leptomeningeal disease recurrence after primary diagnosis. Except for headache grade 2 in two patients, no specific toxicity attributable to IT liposomal cytarabine application was noted. Long-term neurological side effects were not observed. IT liposomal cytarabine therapy with concomitant dexamethasone appears to be feasible and well tolerated.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Antimetabolites, Antineoplastic - administration & dosage
- Antimetabolites, Antineoplastic - adverse effects
- Central Nervous System Neoplasms - drug therapy
- Central Nervous System Neoplasms - secondary
- Cytarabine - administration & dosage
- Cytarabine - adverse effects
- Female -
- Follow-Up Studies -
- Humans -
- Injections, Spinal -
- Liposomes -
- Male -
- Middle Aged -
- Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis
- Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
- Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology
- Treatment Outcome -
- Young Adult -
- Find related publications in this database (Keywords)
- Meningeosis
- adverse events
- relapse