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SHR Neuro Cancer Cardio Lipid Metab Microb

Pollheimer, MJ; Fickert, P; Stieger, B.
Chronic cholestatic liver diseases: clues from histopathology for pathogenesis.
Mol Aspects Med. 2014; 37(2):35-56 Doi: 10.1016/j.mam.2013.10.001
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Leading authors Med Uni Graz: Fickert Peter; Pollheimer Marion
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Abstract:: Chronic cholestatic liver diseases include fibrosing cholangiopathies such as primary biliary cirrhosis or primary sclerosing cholangitis. These and related cholangiopathies clearly display pathologies associated with (auto)immunologic processes. As the cholangiocyte's apical membrane is exposed to the toxic actions of the bile fluid, the interaction of bile with cholangiocytes and the biliary tree in general must be considered to completely understand the pathogenesis of cholangiopathies. While the molecular processes involved in the hepatocellular formation of bile are well understood in both normal and pathophysiologic conditions, those in the bile ducts of normal liver and in livers with cholangiopathies lag behind. This survey highlights key mechanisms known to date that are important for the formation of bile by hepatocytes and its modification by the biliary tree. It also delineates the clinical pathophysiologic findings for cholangiopathies and puts them in perspective with current experimental models to reveal the pathogenesis of cholangiopathies and develop novel therapeutic approaches. Copyright © 2013 Elsevier Ltd. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing): Bile Ducts - pathology; Cholangitis, Sclerosing - pathology Cholangitis, Sclerosing - therapy; Cholestasis - pathology Cholestasis - therapy; Chronic Disease -; Humans -; Liver - pathology; Liver Cirrhosis, Biliary - pathology
Find related publications in this database (Keywords): Animal models; Cholestasis; Cholangiopathies; Liver fibrosis; Primary biliary cirrhosis; Primary sclerosing cholangitis