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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Nardone, R; Höller, Y; Brigo, F; Höller, P; Christova, M; Tezzon, F; Golaszewski, S; Trinka, E.
Fatigue-induced motor cortex excitability changes in subjects with spinal cord injury.
Brain Res Bull. 2013; 99(11):9-12
Doi: 10.1016/j.brainresbull.2013.09.001
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Christova Monica
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- Abstract:
- To further investigate the mechanisms of exercise-induced cortical plasticity after spinal cord injury (SCI), the cortical silent period (CoSP) evoked by transcranial magnetic stimulation (TMS) during a fatiguing muscle contraction was evaluated in 5 patients with incomplete cervical SCI and in 5 healthy subjects. The physiological lengthening of CoSP end latency during fatigue was not observed in the SCI patients. This reduced intracortical inhibition, probably secondary to decreased activity of the GABAergic inhibitory interneurons that modulate the corticomotoneuronal output, could represent a 'positive' neuroplastic response in an attempt to compensate for the loss of corticospinal axons. The investigation of motor cortex excitability during fatiguing exercise may shed light on the role of exercise therapy in promoting brain reorganization and functional recovery in humans. Copyright © 2013 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Electromyography -
- Evoked Potentials, Motor - physiology
- Fatigue - etiology
- Female -
- Humans -
- Male -
- Middle Aged -
- Motor Cortex - physiopathology
- Spinal Cord Injuries - complications
- Transcranial Magnetic Stimulation -
- Find related publications in this database (Keywords)
- Spinal cord injury
- Transcranial magnetic stimulation
- Cortical silent period
- Fatigue
- Exercise