Medizinische Universität Graz - Research portal
Selected Publication:
Gallistl, S; Mangge, H; Neuwirth, G; Muntean, W.
Activation of the haemostatic system in children with juvenile rheumatoid arthritis correlates with disease activity.
Thromb Res. 1998; 92(6):267-272
Doi: 10.1016/S0049-3848(98)00145-5
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- Leading authors Med Uni Graz
- Gallistl Siegfried
- Co-authors Med Uni Graz
- Mangge Harald
- Muntean Eugen
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- Abstract:
- Twenty-four children with juvenile rheumatoid arthritis (JRA) and 10 children with postinfectious arthropathies were investigated for markers of blood coagulation and fibrinolytic activity: Prothrombin fragment 1+2 (F1+2), thrombin-antithrombin complex (TAT), and D-Dimer were measured using solid phase enzyme linked immunosorbent assays (ELISA). Results were compared with clinical and conventional laboratory signs of disease activity. F1+2, TAT, D-Dimer, and fibrinogen were significantly elevated in children with JRA as compared with healthy children and children with postinfectious arthropathies. F1+2, TAT, and D-Dimer correlated significantly with disease activity, assessed by determination of the joint index score and C-reactive protein (CRP). The study demonstrates a subclinical activation of the haemostatic system in children with JRA correlating with disease activity, which might be caused by the action of several immunomediators on cells (monocytes, endothelial cells) playing a role in the regulation of blood coagulation activity.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Antithrombin III - analysis
- Arthritis, Juvenile Rheumatoid - blood Arthritis, Juvenile Rheumatoid - physiopathology
- Blood Coagulation -
- Child -
- Child, Preschool -
- Fibrin Fibrinogen Degradation Products - analysis
- Humans -
- Peptide Fragments - analysis
- Peptide Hydrolases - analysis
- Protein Precursors - analysis
- Prothrombin - analysis
- Find related publications in this database (Keywords)
- Juvenile Rheumatoid Arthritis
- Postinfectious Arthropathies
- Coagulation
- Fibrinolysis