Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Diez-Ruiz, A; Kaiser, G; Jäger, H; Birkmann, J; Tilz, GP; Wachter, H; Fuchs, D.
Increased levels of serum intercellular adhesion molecule 1 in HIV infection are related to immune activation.
INT ARCH ALLERGY IMMUNOL. 1993; 102(1): 56-60.
Doi: 10.1159/000236550
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- Co-Autor*innen der Med Uni Graz
- Tilz Gernot
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- Abstract:
- Cytopathic mechanisms in human immunodeficiency virus type 1 (HIV-1) infection involve syncytia formation, and it appears likely that increased expression of intracellular adhesion molecule 1 (ICAM-1) is involved in these cell adhesion phenomena. In this study, we determined serum concentrations of soluble ICAM-1 (sICAM-1) in 27 patients with HIV-1 infection and a control group. In addition, we compared sICAM-1 values to CD4+ T-cell counts, serum beta 2-microglobulin (beta 2M) and serum neopterin levels. HIV-1-infected patients had significantly higher sICAM-1, beta 2M and neopterin levels than controls. The subgroup of patients with Walter-Reed stages 3-6 had only slightly higher sICAM-1 concentrations in serum than Walter-Reed stages 1-2. The sICAM-1 concentrations in HIV-1-seropositive patients correlated with beta 2M levels but neither with neopterin nor with CD4+ T-cell counts. Increased sICAM-1 may result from immune activation, which enhances the expression of ICAM-1 in patients with HIV-1 infection.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Biopterin - analogs and derivatives
- CD4-Positive T-Lymphocytes - immunology
- Cell Adhesion Molecules - blood
- Female - blood
- HIV Infections - blood
- HIV-1 - immunology
- Humans - immunology
- Intercellular Adhesion Molecule-1 - immunology
- Leukocyte Count - immunology
- Male - immunology
- Middle Aged - immunology
- Neopterin - immunology
- beta 2-Microglobulin - immunology
- Find related publications in this database (Keywords)
- Sicam-1
- Cell Adhesion
- Beta(2)-Microglobulin
- Neopterin
- HIV-1 Infection